EFFECT OF MANDIBULAR POSITION ON CRANIOSKELETAL GROWTH

下颌位置对颅骨生长的影响

• 批准号: 3425391
• 负责人: ARTHUR J MILLER
• 金额: $ 2.08万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425391
• 关键词: bone density; bone development; bone development disorder; cephalometry; computed axial tomography; craniofacial dysostosis; dental radiography; electrodes; electromyography; growth /development; infant animal; laboratory rabbit; mandible /maxilla; mastication; musculoskeletal disorder diagnosis; neuromuscular disorder; pathologic ossification; physiologic bone resorption

The objective is to develop an animal model in the rapidly growing mammal, the rabbit, which is adapting to a mediolateral shift in the mandibular resting posture. The purpose is to determine the effect of the asymmetric rest position on the growth of the cranioskeleton and mandible, the remodeling of this system and the complementary changes in the neuromuscular system. The resting posture of the mandible will be altered mediolaterally by placing similar pole magnets at inclines on the mandibular and maxillary incisors to produce a consistent lateral shift. The first specific aim will determine the effects of changing the mandibular resting position on the contour of bone density within the cranioskeleton. Cranioskeletal changes will be determined by studying bone density distributions assessed with computed tomography in which the density contour of the bone is graphically outlined and quantified, the distribution of density parameters as measured in computed tomography numbers (CT) is displayed and the axial slices are reformatted to compare left and right sides. The second specific aim will determine the effects of changing mandibular resting posture on the growth patterns of this rapidly growing mammal. Growth patterns will be determined radiographically by digitizing and measuring changes in angles and lengths of anatomical sites and metal implanted markers from lateral and postero-anterior cephalograms. This approach will require establishing the techniques of metal implants and assessing mandibular and maxillary changes with techniques similar to those previously used in the primate. The third specific aim will determine the effect of changing the mandibular resting posture on the resting EMG level and the masticatory patterns of the temporalis, medial and lateral pterygoids and masseter muscles. Fine wire electrodes will be placed in the mandibular muscles of the awake, gently restrained rabbit. Statistical analyses of the computer tomography, cephalometric and muscle activity data will be carried out by comparing the same measurement for a given side between the control and experimental animals, as well as evaluating the change in the measurement during the early growth period.

目的是在快速生长的哺乳动物中建立动物模型， 兔子，它正在适应下颌骨的中侧移位， 休息姿势目的是确定非对称性的影响， 休息的位置上的颅骨骼和下颌骨的生长， 这一系统的重塑和互补的变化， 程度的神经肌肉阻滞下颌骨的静止姿势会改变 通过将类似的磁极磁体放置在 下颌和上颌门齿产生一致的侧向移位。 第一个具体目标将决定改变的影响， 下颌骨静息位上的骨密度轮廓内 颅骨通过研究骨骼， 用计算机断层扫描评估密度分布， 骨的密度轮廓被图形化地勾勒和量化， 在计算机断层摄影中测量的密度参数分布 显示数字（CT），并重新格式化轴向切片以进行比较 左右两侧。第二个具体目标将决定效果 改变下颌休息姿势的生长模式， 快速成长的哺乳动物增长模式将由 通过数字化和测量角度和长度的变化， 解剖部位和金属植入标记的横向和 后前位头颅X线片这一办法将需要建立 金属种植体技术与下颌和上颌评估 与先前在灵长类动物中使用的技术类似。 第三个具体目标将决定改变的效果 下颌静息位在静息肌电水平和咀嚼肌 颞肌、翼内、外侧肌和咬肌的形态 肌肉.将细丝电极放置在患者的下颌肌中， 那只醒着的被温柔地约束着的兔子计算机的统计分析 断层扫描、头影测量和肌肉活动数据将由 比较对照组和对照组之间给定侧的相同测量值， 实验动物，以及评估测量的变化 在早期生长期。