EFFECT OF FOOD/TASTE PREFERENCES ON DRUG INTAKE

先天和环境决定因素的相互作用， 对酒精和其他毒品了解甚少。以前的研究，包括 我们自己的初步调查表明：（1）食物匮乏 导致各种自我管理的重大变化， 药物（以及脂肪和甜味偏好的变化）;（2） 大鼠对高脂肪饮食和/或甜味的偏好与以下因素有关 药物自我管理;和（3）大鼠表现出巨大的，先天的 对高脂肪饮食偏好的个体间差异和/或 甜味。因此，我们假设，大鼠不同， 对高脂肪或甜食的偏好在口服自我中会有所不同 酒精、依托硝唑和可卡因的给药。而且我们 假设食物剥夺可能对药物产生不同的影响 大鼠自身给药不同的常量营养素或味道 喜好我们将采用单瓶摄入模式进行初始 研究这些饮食偏好之间的关系 变量和药物自我管理;更细粒度的分析， 这些变量的相互作用将与操作性 条件反射如果饮食和味觉之间的假设关系 确认偏好和药物自我给药，然后进一步 研究味觉和饮食偏好的关系， 药物在人体中的应用。味觉反应的测量 或饮食偏好可以用来筛选那些高风险的人， 过度使用毒品的发展。

The interaction of inborn and environmental determinants of the intake of alcohol and other drugs is poorly understood. Previous studies, including our own preliminary investigations, have shown that: (1) food deprivation causes significant changes in the self-administration of a variety of drugs (as well as changes in fat and sweet taste preference) in rats; (2) the preference of rats for high-fat diets and/or sweet taste is related to drug selfadministration; and (3) rats demonstrate great, innate inter-individual variability in their preference for high-fat diets and/or sweet taste. Therefore, we hypothesize that rats which differ in preference for high-fat or sweet ingesta will differ in oral self administration of alcohol, etonitazene, and cocaine. Furthermore, we hypothesize that food deprivation may have different effects on the drug self-administration of rats with different macronutrient or taste preferences. We will employ a single-bottle intake paradigm for initial investigations of the relationships between these diet preference variables and drug self-administration; more fine-grained analysis of the interactions of these variables will be performed with operant conditioning. If the hypothesized relationships between diet and taste preference and drug self-administration are confirmed, then further investigations into the relationship of taste and diet preferences and drug use in humans are indicated. Potentially, measures of taste response or diet preference could be used to screen for those at high risk for the development of excessive drug use.