OPIOID MEDIATED AFFECTIVE & ANALGESIC EFFECTS OF INGESTION OF PREFERRED FOODS

阿片类药物介导的情感

• 批准号: 3744595
• 负责人: DEAN D KRAHN
• 金额: --
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3744595
• 关键词: analgesia; appetite; brain electrical activity; eating; electroencephalography; endogenous opioid; face expression; food; human subject; naloxone; nutrition related tag; pain threshold; pleasure; preference

We are testing the hypothesis that the ingestion of preferred foods in humans will also release endogenous opiates which will be reflected in changes in pain threshold and/or changes in hedonic state as measured by self-report, facial expression, and left frontal EEG activation. Furthermore, we hypothesize that these changes will be naloxone reversible and that the degree of change in the pain and hedonic measures will differ in subjects who crave ice cream and those who do not crave ice cream.

我们正在验证一个假设，即在一个特定的年龄段， 人类也会释放内源性鸦片剂， 疼痛阈值的变化和/或享乐状态的变化， 自我报告、面部表情和左额叶脑电图激活。 此外，我们假设这些变化将是纳洛酮 可逆的，疼痛和享乐措施的变化程度 会在渴望冰淇淋和不渴望冰淇淋的受试者中有所不同。 冰淇淋