Understanding the molecular basis of heparanase activity

了解乙酰肝素酶活性的分子基础

• 批准号: LP160101552
• 负责人: Prof Colin Jackson
• 金额: $ 29.84万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-07-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160101552
• 关键词: Understanding; molecular; basis; heparanase; activity

This project aims to advance our understanding of the structure and impact on biological processes of heparanase (HSPE), an enzyme of critical importance. HSPE’s ability to interact with heparan sulfate (HS), a key component of the extracellular matrix and basement membranes, makes HPSE a pivotal enzyme in many important physiological and disease-related processes ranging from angiogenesis, tumour metastasis, inflammation, hair follicle development to wrinkle formation. The knowledge gained through this project is expected to provide new insight into the interaction between HSPE and HS/HSPG to reveal new pathways to the development of inhibitors to treat diseases such as cancer and diabetes.

本项目旨在促进我们对乙酰肝素酶(HSPE)的结构及其对生物过程的影响的了解，HSPE是一种至关重要的酶。HSPE能够与细胞外基质和基底膜的关键成分硫酸乙酰肝素(HS)相互作用，使HPSE成为许多重要的生理和疾病相关过程中的关键酶，从血管生成、肿瘤转移、炎症、毛囊发育到皱纹形成。通过该项目获得的知识有望为HSPE和HS/HSPG之间的相互作用提供新的见解，以揭示开发治疗癌症和糖尿病等疾病的抑制剂的新途径。