Protein design

蛋白质设计

• 批准号: DP170100181
• 负责人: Prof Colin Jackson
• 金额: $ 33.99万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100181
• 关键词: Protein; design

This project aims to design binding specificity in proteins in a rational way. Extending the existing repertoire of protein specificity using engineering principles should harness the catalytic power and high binding affinities of natural proteins. By building upon protein design algorithms, this project will develop biosensors for neurotransmitters and specialist enzymes to incorporate unnatural amino acids. It will iteratively improve the designs and algorithms by computational and experimental characterisation. The outcomes should address the long-standing need in synthetic biology for a facile route to designer proteins

本项目旨在合理设计蛋白质的结合特异性。利用工程原理扩展现有的蛋白质特异性，应该利用天然蛋白质的催化能力和高结合亲和力。通过建立蛋白质设计算法，该项目将开发神经递质和特殊酶的生物传感器，以结合非天然氨基酸。它将通过计算和实验表征迭代地改进设计和算法。这一结果将解决合成生物学长期以来对设计蛋白的便捷途径的需求