NEURAL ASSEMBLIES--PLASTICITY IN AUDITORY CORTEX

神经组装——听觉皮层的可塑性

• 批准号: 3217951
• 负责人: GEORGE L GERSTEIN
• 金额: $ 17.21万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3217951
• 关键词: auditory cortex; auditory stimulus; brain electrical activity; brain mapping; computational neuroscience; histology; laboratory rat; model design /development; neural information processing; neural plasticity; sound frequency

We propose to study cortical organization and reorganization at the level of neuronal networks and assemblies, using both experimental and theoretical methods. The experimental vehicle will be rat auditory cortex subjected to local electrical stimulation; in analogy to work done by others as well as in our laboratory on somatosensory cortex, this procedure should force changes in the auditory frequency and ear dominance 'map' arrangement. During such changes we propose to make extracellular recordings simultaneously and separably from 10-30 neurons in the reorganizing cortical region. These measurements and their subsequent interpretation in terms of neuronal assembly processes will rest on recording technologies and analytic mathematics that have largely been developed by our laboratory over the last decade. The proposed theoretical work will examine computer simulations of neuronal networks arranged to reproduce the changes in map magnification and boundaries which underlie the experimental work. As information about 'effective connectivity' and neuronal assembly properties emerges from the experiments. these now constraints will be incorporated into the ongoing modeling. The models will be studied on both a gross level, and on a 'microscopic' scale, using our standard spike train analysis techniques, and are likely to suggest additional experimental measurements. The overall project should give considerable insight into actual and possible mechanisms for cortical modularity and reorganization; we will here have direct experimental access to the details of the process by which the brain allocates its computational resources. Comparison of the auditory work to the analogous somatosensory project will test the extent to which the reorganization processes are universal across sensory systems, or conversely whether they will prove to be unique.

我们建议在该水平上研究皮质组织和重组 神经元网络和组件，都使用实验和 理论方法。 实验工具将是大鼠听觉 皮质受到局部电刺激；类似于完成的工作 在其他以及我们关于体感皮质的实验室中，这 程序应迫使听觉频率和耳朵变化 优势“地图”布置。 在此类更改期间，我们建议 细胞外记录同时且与10-30个神经元分离 在重组皮质区域。 这些测量及其 随后根据神经元组装过程的解释将 基于录制技术和分析数学 是在过去十年中由我们的实验室开发的。 提议 理论工作将检查神经元网络的计算机模拟 布置用于重现地图放大和边界的变化 这是实验工作的基础。 作为有关'有效的信息 连接性'和神经元组装属性从 实验。这些现在的约束将被纳入正在进行的 造型。 这些模型将在总级别和 使用我们的标准尖峰火车分析技术的“微观”量表， 并可能提出其他实验测量。 这 总体项目应该对实际和可能的大量见解 皮质模块化和重组的机制；我们将在这里有 直接实验访问该过程的细节 大脑分配其计算资源。 听觉的比较 与类似的体感项目一起工作将测试 重组过程在感觉系统之间是普遍的，或 相反，它们是否将被证明是独一无二的。