SuperSpiderSilkScaffolds: Exemplification of chemically decorated spider silk in wound healing

SuperSpiderSilkScaffolds：化学修饰蜘蛛丝在伤口愈合中的实例

• 批准号: BB/N012658/1
• 负责人: Neil Thomas
• 金额: $ 25.65万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN012658%2F1
• 关键词: SuperSpiderSilkScaffolds; Exemplification; chemically; decorated; spider

Spider silk is tougher than steel or Kevlar used in bulletproof vests on a weight per weight basis. It is a biocompatible material that does not cause excess inflammation or a significant immune response making it ideal for use in new wound dressings and scaffolds for tissue regeneration. These could both accelerate healing and potentially reduce permanent scarring. Spider silks are biodegradable and sustainable natural materials composed of a number of different proteins that self-assemble to form fibers and films. Unlike silkworms, spiders cannot be farmed as they are cannibalistic and only recently have reliable recombinant methods been developed. Building on these, we have developed a method of producing spider silk in bacteria which carry antibiotics for keeping wounds free of infection and/or ligands to promote tissue regeneration. We wish to optimize the production of these new silks to promote faster wound healing especially for chronic sores and pressure ulcers as in diabetes.

蜘蛛丝比钢或防弹衣中使用的凯夫拉纤维更坚韧。它是一种生物相容性材料，不会引起过度炎症或显著的免疫反应，因此非常适合用于新的伤口敷料和组织再生支架。这些都可以加速愈合，并有可能减少永久性疤痕。蜘蛛丝是可生物降解和可持续的天然材料，由许多不同的蛋白质组成，这些蛋白质自组装形成纤维和薄膜。与蚕不同，蜘蛛不能被养殖，因为它们是同类相食的，直到最近才开发出可靠的重组方法。在此基础上，我们开发了一种在细菌中产生蜘蛛丝的方法，该细菌携带抗生素以保持伤口免受感染和/或配体以促进组织再生。我们希望优化这些新丝绸的生产，以促进伤口更快愈合，特别是慢性溃疡和糖尿病压力溃疡。

项目成果

Laboratory News - Silky Smooth Solution

实验室新闻 - 丝滑解决方案

• 发表时间: 2017
• 作者: Harvey D