Harnessing Self assembly to generate a spectrum of multi-functionalised nanoparticles for multimodal imaging

利用自组装生成一系列用于多模态成像的多功能纳米颗粒

• 批准号: G0801741/1
• 负责人: Neil Thomas
• 金额: $ 65.83万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0801741%2F1
• 关键词: Harnessing; Self; assembly; generate; spectrum

We will use a protein that can self assemble from its subunits into a capsule as a vehicle for imaging inside patients using magnetic resonance or tomography and in the longer term delivering drugs to specific tissues such as tumours. As the individual building blocks of the protein capsule can be modified in different ways, the capsule can be optimised on an individual basis based on patient need.

我们将使用一种可以从其亚基自组装成胶囊的蛋白质作为载体，通过磁共振或断层扫描在患者体内成像，并从长远来看将药物输送到特定组织，如肿瘤。由于蛋白质胶囊的单个构建块可以以不同的方式进行修改，因此胶囊可以根据患者的需要进行个性化优化。