An integrated upper GI model of digestion and absorption - the commercial 'Holy Grail'

消化和吸收的综合上消化道模型 - 商业“圣杯”

• 批准号: BB/N012666/1
• 负责人: Jeff Pearson
• 金额: $ 19.46万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN012666%2F1
• 关键词: integrated; upper; GI; model; digestion

Modelling the processes of digestion, nutrient uptake and drug absorption in the laboratory reduces the need to carry out expensive and controversial studies in animals and humans. We aim to develop a fully integrated lab model of digestion and absorption to screen and develop new drugs and health interventions. The commercial need in the pharmaceutical industry for this model has been identified during a BBSRC Enterprise Fellowship and validated through independent market research funded by a BBSRC Pathfinder award, and we have applied for a patent of this technology. This integrated model has been described as the 'Holy Grail' and would allow food and pharmaceutical companies to carry out affordable screening and development studies to inform product development and drug discovery. This would significantly reduce the high costs of drug development. Furthermore an effective, validated model of digestion would reduce the need for a great number of animal studies.

在实验室中模拟消化、营养吸收和药物吸收的过程，减少了在动物和人类身上进行昂贵和有争议的研究的需要。我们的目标是开发一个完全集成的消化和吸收实验室模型，以筛选和开发新药和健康干预措施。制药行业对该模型的商业需求已在BBSRC企业奖学金期间得到确定，并通过BBSRC探路者奖资助的独立市场研究进行了验证，我们已申请了该技术的专利。这种综合模式被称为“圣杯”，将使食品和制药公司能够进行负担得起的筛选和开发研究，为产品开发和药物发现提供信息。这将大大降低药物开发的高成本。此外，一个有效的、经过验证的消化模型将减少对大量动物研究的需求。

项目成果

The effect of seaweed enriched bread on carbohydrate digestion and the release of glucose from food.

• DOI: 10.1016/j.jff.2021.104747
• 发表时间: 2021-12
• 期刊: Journal of functional foods
• 影响因子: 5.6
• 作者: Wilcox MD;Cherry P;Chater PI;Yang X;Zulali M;Okello EJ;Seal CJ;Pearson JP
• 通讯作者: Pearson JP