Nonlinear wave interactions in the cochlea and their application to sound processing
耳蜗中的非线性波相互作用及其在声音处理中的应用
基本信息
- 批准号:10577844
- 负责人:
- 金额:$ 20.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAffectAnatomyAuditoryAuditory PerceptionBasilar MembraneBehavioralCaviaCharacteristicsChinchilla (genus)CochleaComplexComputer ModelsCoupledCouplingDataDependenceDimensionsEarFelis catusFrequenciesGerbilsGoalsHealthHearingHumanImpairmentLaboratory AnimalsLiquid substanceLocationMapsMathematicsMeasuresMechanicsModelingMusNoiseNon-linear ModelsOuter Hair CellsPatternPerformancePeripheralPhysiologicalPlayProceduresProcessPropertyRoleSelf-Help DevicesSensorineural Hearing LossShapesSignal TransductionStimulusStructureTechnologyTestingdata modelingdesigndetectordirect applicationhearing impairmenthuman modelimprovedmathematical analysisnovelotoacoustic emissionresponserole modelsoundthree-dimensional modelingwaveguide
项目摘要
Project Abstract/Summary
The mammalian cochlea achieves its outstanding performance characteristics by including a physiologically vul-
nerable active process that strategically amplifies waves as they propagate through the cochlear spiral. As a
result of this spatially coordinated and nonlinear wave amplification, the cochlear response at one characteristic-
frequency location largely depends upon the physiological status and the response in more basal regions. In
response to complex sounds, waves of different frequency nonlinearly interact along the cochlea, mutually sup-
pressing one with the other. In contrast to a bank of independently operating filters commonly used to depict
cochlear function, the responses of distinct “cochlear filters" are strongly coupled by nonlinear wave interactions.
Although nonlinear wave interactions play a major role for the cochlea response, their role for encoding complex
sounds in the auditory periphery—and consequently their contribution to central auditory mechanisms—is poorly
understood and largely ignored.
Understanding nonlinear wave interactions is hence essential to establish how the cochlea encodes eco-
logically relevant sounds and the role of the auditory periphery for sound perception. Because nonlinear wave
interactions depend upon the health of the ear, understanding these interactions is fundamental also to establish
how cochlear impairment affects the peripheral representation of complex sounds. Further, because even mild
sensorineural hearing loss greatly degrades behavioral performance in acoustically challenging situations, it is
likely that nonlinear wave interactions underlie unexplored mechanisms for the outstanding performance of the
healthy ear.
My project will tackle these issues by: (i) deriving from the experimental data a cochlear model that reproduces
accurately nonlinear wave interactions in laboratory animals (Aim 1.a) and humans (Aim 1.b); (ii) testing the
hypothesis that nonlinear wave interactions underly beneficial mechanisms to encode sounds in acoustically
adverse situations (Aim 2.a), and (iii) determining how and with what limitations the effects of nonlinear wave
interactions elucidated in this project are accounted for by popular computer models of the auditory periphery
(Aim 2.b). The results of this project will not only challenge and improve the current understanding of cochlear
function for hearing, but will also find natural application in improving models of hearing impairment, and in
determining novel cochlear-inspired strategies to improve the performance of assistive hearing technology.
项目摘要/总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alessandro Altoe其他文献
Alessandro Altoe的其他文献
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{{ truncateString('Alessandro Altoe', 18)}}的其他基金
Nonlinear wave interactions in the cochlea and their application to sound processing
耳蜗中的非线性波相互作用及其在声音处理中的应用
- 批准号:
10427031 - 财政年份:2022
- 资助金额:
$ 20.63万 - 项目类别:
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