ROLE OF H-2 IN ORAL-FACIAL DEVELOPMENT

哺乳动物主要组织相容性复合体(H-2) 小鼠；人类的人类白细胞抗原)是一个多基因家族，其成员 编码细胞表面糖蛋白。最近，人们一直在关注 关注与MHC相关的可能的非免疫功能 基因。众所周知，有一个或多个主效基因 与影响前和后的H-2复合体有关 着床发育包括第一次卵裂的时机 组织，类固醇受体数量和反应性， 下颌骨和其他面部结构的形态发生和 胎儿的总体生长和存活情况。所有这些性状的变异 与H-2单倍型变异有关。有鉴于此，我们将(A) H-2单倍型之间关系的形态计量学分析 以及特征变化(例如，线性、角度和面积 同基因小鼠13-17天的头面部生长 (B)确定是否存在母体影响 (遗传型、细胞质等)和(C)确定 同源菌株间的总表型变异 对环境变化的影响。因为某些致畸物质 (皮质类固醇、苯妥英)对颅面有干扰作用 发育和诱发这种畸形的能力 与H-2单倍型相关，我们将重复所有实验 在对这些畸形菌进行产妇治疗后。

The major histocompatability complex (MHC) of mammals (H-2 in mice; HLA in humans) is a multigene family whose members encode cell-surface glycoproteins. Recently, attention has been focused on possible non-immune functions of MHC associated genes. It is known that there are one or more major genes associated with the H-2 complex that influence pre- and post- implantation development including timing of the first cleavage division, steroid receptor number and responsiveness, morphogenesis of the mandible and other facial structures and overall fetal growth and survival. Variation in all of these traits is related to variation in H-2 haplotype. Given this, we will (a) morphometrically analyze the relationship between H-2 haplotype and the characteristic changes (e.g. linear, angular, and area dimensions) in craniofacial growth of congenic mice 13 - 17 days of gestation, (b) determine the existence of maternal effects (genotypic, cytoplasmic, etc.) and (c) determine the proportion of the total phenotypic variation among congenic strains that is due to environmental variation. Since certain teratogens (corticosteroids, phenytoin) are known to disturb craniofacial development and their ability to induce such malformations is associated with H-2 haplotype, we will repeat all experiments after maternal treatment with these teratogens.