ROLE OF H-2 IN ORAL-FACIAL DEVELOPMENT

哺乳动物的主要组织相容性复合体（MHC）（H-2， 小鼠;人类的HLA）是一个多基因家族，其成员 编码细胞表面糖蛋白。 最近，人们注意到， 关注MHC相关的可能的非免疫功能， 基因. 已知有一个或多个主基因 与H-2复合体有关， 着床发育，包括第一次卵裂的时间 分裂，类固醇受体数量和反应性， 下颌骨和其他面部结构的形态发生， 总体胎儿生长和存活。 所有这些特征的变异 与H-2单倍型变异有关。 因此，我们将（a） 形态计量学分析H-2单倍型之间的关系 并且特征变化（例如，线性、角度和面积 尺寸）的同类小鼠13 - 17天的颅面生长 （B）确定是否存在母体效应 （基因型、细胞质等）及（c）决定以下各项的比例 同类菌株间的总表型变异， to environmental环境variation变化. 因为某些致畸物质 （皮质类固醇，苯妥英）已知会干扰颅面 发育和它们诱导这种畸形的能力是 与H-2单倍型相关，我们将重复所有实验 在母亲用这些致畸剂治疗后。

The major histocompatability complex (MHC) of mammals (H-2 in mice; HLA in humans) is a multigene family whose members encode cell-surface glycoproteins. Recently, attention has been focused on possible non-immune functions of MHC associated genes. It is known that there are one or more major genes associated with the H-2 complex that influence pre- and post- implantation development including timing of the first cleavage division, steroid receptor number and responsiveness, morphogenesis of the mandible and other facial structures and overall fetal growth and survival. Variation in all of these traits is related to variation in H-2 haplotype. Given this, we will (a) morphometrically analyze the relationship between H-2 haplotype and the characteristic changes (e.g. linear, angular, and area dimensions) in craniofacial growth of congenic mice 13 - 17 days of gestation, (b) determine the existence of maternal effects (genotypic, cytoplasmic, etc.) and (c) determine the proportion of the total phenotypic variation among congenic strains that is due to environmental variation. Since certain teratogens (corticosteroids, phenytoin) are known to disturb craniofacial development and their ability to induce such malformations is associated with H-2 haplotype, we will repeat all experiments after maternal treatment with these teratogens.