RESPONSES FROM CHORDA TYMPANI & GLOSSOPHARYNGEAL NERVES

鼓弦的回应

• 批准号: 3216220
• 负责人: LLOYD M. BEIDLER
• 金额: $ 7.72万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3216220
• 关键词: cell differentiation; chemoreceptors; chorda tympani; cranial nerves; electrophysiology; hypoglossal nerve; innervation; laboratory rat; stimulus /response; taste

A comparison of taste responses from the fungiform, foliate and circumvallate papillae will be studied by simultaneous recording from the chorda tympani and glossopharyngeal nerves. Hypoglossal stimulation will be used to increase the transport rate of the taste stimulus to the taste buds of the circumvallate and foliate papillae by mechanical movement of the tongue. The effectiveness of a variety of bitter stimuli will be measured by response-concentration functions. The hypothesis that "the relative reactivity of taste receptor cells to different chemicals is determined by inherent properties of the tissue from which the cells are formed" will be tested by simultaneous recording of chorda tympani and glossopharyngeal nerve bundles that innervate the foliate papillae. The taste system is excellent for study of the general problem of molecule-cell interactions that are so important in biology and medicine. Since the taste cells are rapidly renewed, the process of cell differentiation can also be studied by examining the importance of nerve contact in taste cell differentiation. Bitterness is of great importance in the development of both rodenticides and medicines.

菌形、叶状和叶状的味觉反应比较 环状乳突将通过同步记录来研究 鼓索和舌咽神经。舌下神经刺激将 用于增加味觉刺激到味觉的传输率 环状乳突和叶状乳突的萌发 舌头。各种苦涩刺激的效果将是 通过响应-浓度函数来衡量。这一假设是“The 味觉感受器细胞对不同化学物质的相对反应性是 由细胞所来自的组织的固有属性决定 形成的“将通过同时记录鼓索和 舌咽神经束，支配叶状乳头。 味觉系统是研究一般问题的最佳选择 在生物学和医学中非常重要的分子-细胞相互作用。 由于味觉细胞迅速更新，细胞的过程 区分也可以通过检查神经的重要性来研究。 接触味觉细胞分化。苦涩是非常重要的 在灭鼠剂和药物的开发方面。