EFFECT OF AGE ON TASTE

年龄对味觉的影响

• 批准号: 3117916
• 负责人: LLOYD M. BEIDLER
• 金额: $ 16.25万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3117916
• 关键词: aging; biological models; cell growth regulation; cell migration; electrophysiology; epithelium; peripheral nervous system; stimulus /response; taste; taste threshold; testosterone; vinblastine

The objective is to understand the role of taste cell renewal in the aging process. Food identification difficulties and a lack of proper nutrition have been noted in the elderly. The role of taste in these deficiencies is not understood. A likely physiological change in taste for the elderly is a slowing down of taste cell renewal. The relationship between taste perception and taste cell renewal is not known. The specific aims are: (1) Compare taste cell renewal in young and old Fischer-344 rats. (2) Simultaneously, the functioning of the taste system of young and old rats will be studies to note any decrease in sensitivity with age, using a comprehensive analysis of behavior in the presence of a variety of tastants and by electrophysiological recordings from peripheral taste nerves, including those from the palate. (3) Finally, changes in taste bud renewal will be experimentally introduced by injecting vinblastine sulfate, which arrests mitosis in its metaphase and by injecting testosterone, which alters the life cycle of the taste cells. The effects of these changes will be measured both by recording the neural changes in the taste nerves and by thoroughly studying the taste behavior of the rat.

目的是了解味觉细胞更新在衰老中的作用 进程。食物识别困难和缺乏适当的营养 已经在老年人身上发现了。品味在这些缺陷中的作用是 我不明白。老年人口味的一个可能的生理变化是 味觉细胞更新速度减慢。品味之间的关系 感知和味觉细胞更新尚不清楚。具体目标是： (1)比较青年和老年Fischer-344大鼠的味觉细胞更新。 (2)同时，青年和老年人味觉系统的功能 将对大鼠进行研究，以记录任何随年龄增长的敏感度下降，使用 在不同品尝者面前对行为的综合分析 并通过来自周围味觉神经的电生理记录， 包括那些来自味觉的。 (3)尝试性地介绍味蕾更新的变化。 通过注射硫酸长春花碱阻止中期有丝分裂 通过注射睾丸激素，它改变了味道的生命周期 细胞。这些变化的影响将通过记录 味觉神经的神经变化和深入研究味觉 老鼠的行为。