EFFECT OF AGE ON TASTE

目的是了解味觉细胞更新在衰老中的作用 过程 食物鉴别困难和缺乏适当营养 在老年人中也有发现。 味觉在这些缺陷中的作用是 不明白。 老年人味觉的一个可能的生理变化是 味觉细胞更新的减缓。 味觉与 感知和味觉细胞更新是未知的。 具体目标是： (1)比较年轻和老年Fischer-344大鼠的味觉细胞更新。 (2)与此同时，年轻人和老年人的味觉系统 将对大鼠进行研究，以记录敏感性随年龄的任何降低，使用 在多种促味剂存在下的行为的综合分析 并且通过来自外周味觉神经的电生理记录， 包括上颚的 (3)最后，将实验性地介绍味蕾更新的变化 通过注射硫酸长春碱， 通过注射睾丸激素， 细胞 这些变化的影响将通过记录 味觉神经的神经变化，并通过彻底研究味觉， 老鼠的行为

The objective is to understand the role of taste cell renewal in the aging process. Food identification difficulties and a lack of proper nutrition have been noted in the elderly. The role of taste in these deficiencies is not understood. A likely physiological change in taste for the elderly is a slowing down of taste cell renewal. The relationship between taste perception and taste cell renewal is not known. The specific aims are: (1) Compare taste cell renewal in young and old Fischer-344 rats. (2) Simultaneously, the functioning of the taste system of young and old rats will be studies to note any decrease in sensitivity with age, using a comprehensive analysis of behavior in the presence of a variety of tastants and by electrophysiological recordings from peripheral taste nerves, including those from the palate. (3) Finally, changes in taste bud renewal will be experimentally introduced by injecting vinblastine sulfate, which arrests mitosis in its metaphase and by injecting testosterone, which alters the life cycle of the taste cells. The effects of these changes will be measured both by recording the neural changes in the taste nerves and by thoroughly studying the taste behavior of the rat.