BIOPSY AND ANALYSIS OF 5 TO 10 YEAR OLD COMPOSITES

5 至 10 年前复合材料的活检和分析

• 批准号: 3221783
• 负责人: Stephen C. Bayne
• 金额: $ 14.64万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3221783
• 关键词: biomaterial evaluation; composite resins; dental material wear; information systems

The Operative Dentistry Clinical Research Program at the University of North Carolina maintains the largest database of information on dental composite research patients. During the past 10 years, 15 projects have been conducted. Many of the restorations are now in the 5 to 10 year old category and will require replacement shortly. This provides a unique opportunity to remove, recover, and analyze restorations that are fully characterized and have a long history of clinical evaluation data. The objective of this proposal is to use (a) clinical evaluation wear data, (b) microstructural and microchemical data from biopsies, and (c) published property values to test the validity of current composite wear theories. Biopsies will be collected from pre-selected patients to (1) explain differences between patients with high wear rates vs low wear rates, (2) evaluate specific intraoral location factors such as anterior vs posterior, molar vs premolar, class 1 vs class 2, and occlusal contact areas vs non-contact areas, and (3) evaluate differences in wear rates between early periods of service at 1 to 3 years and wear rates after long periods of service from 5 to 10 years. Biopsies will then be sectioned in half and polished to provide samples for both SEM microstructural analyses and FTIR microchemical analyses. SEM measurements of microfractures, pores, and cracks will be used to assess current mechanical wear theories. FTIR analyses of chemical composition and degree of conversion will be used to evaluate current chemical degradation theories. Information in both cases will be collected on both superficial and interior zones for comparison. Information from clinical evaluations, laboratory analyses, and published properties will be statistically examined for correlations of wear with causal relationships.

密歇根大学口腔外科临床研究项目 北卡罗来纳州维护着最大的牙科信息数据库 综合研究病人。在过去的10年里，有15个项目 已经进行过了。现在许多修复都是在5到10岁之间 类别，不久将需要更换。这提供了一种独特的 删除、恢复和分析完全恢复的机会 具有特点并具有悠久历史的临床评估数据。这个 本提案的目的是使用(A)临床评估磨损数据，(B) 活检的显微结构和微化学数据，以及(C)公布 属性值来检验当前复合磨损理论的有效性。 将收集预先选定的患者的活组织检查，以(1)解释 高磨损率和低磨损率患者之间的差异，(2) 评估特定的口腔内位置因素，如前部和后部， 磨牙与前磨牙、1类与2类、咬合接触面积与 非接触区，以及(3)评估早期磨损率的差异 服务年限为1至3年及长时间服务后的磨损率 服务年限为5至10年。 然后活检将被切成两半并打磨，以提供样本用于 扫描电子显微镜显微结构分析和FTIR显微化学分析。扫描电镜 将使用微裂缝、孔洞和裂缝的测量来评估 目前的机械磨损理论。傅立叶变换红外光谱分析化学成分 并将使用转化率来评估当前的化学品 退化理论。这两个案例的信息都将收集在两个 用于比较的表面区和内部区。 来自临床评估、实验室分析和出版的信息 将对性能进行统计检查，以确定磨损与 因果关系。