Increasing Micronutrient Bioavailability from Wheat

提高小麦微量营养素的生物利用度

基本信息

  • 批准号:
    BB/N021002/1
  • 负责人:
  • 金额:
    $ 52.29万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2016
  • 资助国家:
    英国
  • 起止时间:
    2016 至 无数据
  • 项目状态:
    已结题

项目摘要

Nutritional deficiency in essential dietary metals such as iron and zinc is a public health concern in the UK, particularly for girls and young women. Approximately 30 - 50% of the iron and zinc in the UK diet is provided by cereals and cereal products (e.g. bread, breakfast cereals and baked goods). However, in wholegrain wheat, most of the iron and zinc is physically contained within a single layer of cells called the aleurone layer. Our recent work shows that aleurone cells are resistant to physical disruption and digestion as they pass along the gastrointestinal tract and are excreted intact in faeces. The aleurone layer is removed during processing of wheat into white flour and hence much of the iron and zinc is lost. While iron is added back into white flour at the milling stage, there is currently no addition of zinc. The aim of this study is to use novel food processing techniques to increase the bioavailability of the naturally-occurring iron and zinc in wheat. This process, called micro-milling, ruptures the aleurone cell walls and potentially makes the iron and zinc more available for absorption. In addition, we will use purified aleurone which has been micro-milled to enrich white flour with iron and zinc. Our recently published work shows that micro-milling increases the solubility of iron and enhances iron absorption by intestinal epithelial cells, and we expect the same to be true for zinc.The main purpose of our proposal is to build on recently published data and further characterise iron and zinc availability from micro-milled wheat flour. We hypothesize that micro-milling will increase iron and zinc availability from wholegrain flour and from aleurone-enriched white flour. Next, we will carry out human intervention studies to assess iron and zinc bioavailability from bread rolls manufactured from micro-milled wholegrain flour or from white flour enriched with micro-milled aleurone flour. Here we hypothesize that bioavailability of both iron and zinc will be enhanced in foods containing micro-milled flour compared with standard-milled flour. Finally, we will analyse the structure of breads produced using micro-milled wheat flour and assess consumer acceptability of these products in a range of sensory tests. Our hypothesis is that micro-milling will not adversely affect food structure or consumer acceptability. We believe that our research strategy will increase the nutritional quality of food products manufactured from wholegrain wheat, and potentially have health benefits for those at risk of iron and zinc deficiency. Furthermore, our studies might identify micro-milled aleurone as a potential functional food ingredient for use in fortifying or enriching cereal-based products to increase iron and zinc content and bioavailability.
在英国,铁和锌等必需膳食金属的营养缺乏是一个公共卫生问题,特别是对女孩和年轻妇女。英国饮食中约30 - 50%的铁和锌由谷物和谷物产品(如面包,早餐谷物和烘焙食品)提供。然而,在全麦小麦中,大部分铁和锌物理上包含在称为糊粉层的单层细胞中。我们最近的工作表明糊粉细胞在沿着胃肠道通过并在粪便中完整排泄时对物理破坏和消化具有抵抗力。在小麦加工成白色面粉的过程中,糊粉层被除去,因此大量的铁和锌被损失。虽然铁在碾磨阶段被添加回白色面粉中,但目前没有添加锌。本研究的目的是使用新的食品加工技术来提高小麦中天然存在的铁和锌的生物利用度。这一过程被称为微磨,它破坏了糊粉细胞壁,并可能使铁和锌更容易被吸收。此外,我们还将使用经过微磨的纯化糊粉来使白色面粉富含铁和锌。我们最近发表的工作表明,微磨增加铁的溶解度,并增强肠上皮细胞对铁的吸收,我们希望同样适用于锌。我们建议的主要目的是建立在最近发表的数据和进一步提高铁和锌的微磨小麦粉的可用性。我们推测,微磨将增加全麦面粉和糊粉丰富的白色面粉的铁和锌的可用性。接下来,我们将进行人类干预研究,以评估铁和锌的生物利用度从面包卷制造的微磨全麦面粉或从白色面粉富含微磨糊粉。在这里,我们假设,铁和锌的生物利用度将提高食品中含有微磨面粉与标准面粉相比。最后,我们将分析使用微磨小麦粉生产的面包的结构,并在一系列感官测试中评估消费者对这些产品的接受程度。我们的假设是,微磨不会对食品结构或消费者的可接受性产生不利影响。我们相信,我们的研究策略将提高由全麦小麦制成的食品的营养质量,并可能对那些有铁和锌缺乏风险的人有益。此外,我们的研究可能会确定微粉碎糊粉作为一种潜在的功能性食品成分,用于强化或丰富谷物产品,以增加铁和锌的含量和生物利用度。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Strategies to increase the bioaccessibility and bioavailability of iron and zinc from cereal products.
提高谷物产品中铁和锌的生物可及性和生物利用度的策略。
Micro-milling increases iron bioaccessibility from wheat flour
微粉碎提高了小麦粉中铁的生物可利用性
Enhancing mineral bioavailability from cereals: Current strategies and future perspectives.
  • DOI:
    10.1111/nbu.12324
  • 发表时间:
    2018-06
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Aslam MF;Ellis PR;Berry SE;Latunde-Dada GO;Sharp PA
  • 通讯作者:
    Sharp PA
P11-055-23 Wheat Aleurone Provides a Bioavailable Source of Iron for Fortifying Wheat-Based Foods
P11-055-23 小麦糊粉层为强化小麦食品提供生物可利用的铁源
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Paul Sharp其他文献

永小作権
永久租赁权
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stephen Broadberry;Kyoji Fukao;Paul W. Rhode;Paul Sharp;Tracy Dennison;Alexander Klein;Tokihiko Settsu;Debin Ma;Gregg Huff;Mohamed Saleh;Pablo Astorga;Alfonso;Ewout Frankema;Gary B. Magee;Latika Chaudhary;Peter Lindert;Rajabrata Banerjee;西丸良一;宮島英昭;小柳春一郎
  • 通讯作者:
    小柳春一郎
nipy/nipype: 1.4.2
尼皮/尼皮佩:1.4.2
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Oscar Esteban;Christopher J. Markiewicz;Hans Johnson;Erik Ziegler;Alexandre Manhães;Dorota Jarecka;Christopher Burns;David Gage Ellis;Carlo Hamalainen;Michael Notter;Benjamin Yvernault;Taylor Salo;Michael Waskom;Mathias Goncalves;Kesshi Jordan;Jason Wong;Blake E Dewey;Cindee Madison;Erin Benderoff;Daniel Clark;Fred Loney;Dav Clark;Anisha Keshavan;Michael Joseph;Dylan M. Nielson;Michael Dayan;Marc Modat;Alexandre Gramfort;Salma Bougacha;Basile Pinsard;Shoshana L. Berleant;Horea Christian;Ariel Rokem;Matteo Visconti di Oleggio Castello;Yaroslav O. Halchenko;Jakub Kaczmarzyk;Gaël Varoquaux;Rastko Ćirić;Brendan Moloney;Elizabeth DuPre;Serge Koudoro;Michael G. Clark;Ben Cipollini;Demian Wassermann;Jérémy Guillon;Ross D. Markello;Michael Hanke;Colin Buchanan;Rosalia Tungaraza;Ashley Gillman;Wolfgang M. Pauli;Gilles de Hollander;Sharad Sikka;Jessica Forbes;David Mordom;Shariq Iqbal;Matteo Mancini;Ian B. Malone;Mathieu Dubois;Yannick Schwartz;Caroline Frohlich;Alejandro Tabas;David Welch;Adam Richie;Steven Tilley;Aimi Watanabe;B. N. Nichols;Julia M. Huntenburg;Arman Eshaghi;D. Ginsburg;Alexander Schaefer;Katherine L. Bottenhorn;Chad Cumba;Benjamin Acland;Anibal Sólon Heinsfeld;Erik Kastman;James D. Kent;Jens Kleesiek;Ali Ghayoor;Drew Erickson;Steven Giavasis;Alejandro de la Vega;Franz Liem;René Küttner;Martin Felipe Perez;John Aldo Lee;Jarrod Millman;Jeff Lai;Dale Zhou;Christian Haselgrove;Daniel Glen;Anna Doll;Mandy Renfro;Carlos Correa;Siqi Liu;Leonie Lampe;Xiang;Michael Hallquist;Sin Kim;Ari E. Kahn;Tristan Glatard;William Triplett;Kshitij Chawla;J. Salvatore;Fernando Pérez;Feilong Ma;Anne Park;R. C. Craddock;Oliver P. Hinds;Russell A. Poldrack;L. Perkins;Hrvoje Stojic;Andrey Chetverikov;Souheil Inati;Martin Grignard;Lukas Snoek;Lucinda M. Sisk;Katrin Leinweber;Junhao Wen;Sebastian Urchs;Ross Blair;K. Matsubara;Andrew Floren;Aaron Mattfeld;Stephan Gerhard;Jörg Stadler;Gavin Cooper;Daniel Haehn;William Broderick;Sami Kristian Andberg;Maxime Noel;Matthew Cieslak;Joke Durnez;Eric Condamine;Dimitri Papadopoulos Orfanos;Daniel Geisler;B. Meyers;Arielle Tambini;Alejandro Weinstein;Abel A. González Orozco;Robbert Harms;Ranjeet Khanuja;Paul Sharp;Olivia Stanley;Nat Lee;Michael R. Crusoe;Matthew Brett;Marcel Falkiewicz;Leon Weninger;Kornelius Podranski;Janosch Linkersdörfer;Guillaume Flandin;Garikoitz Lerma;Claire Tarbert;Brian Cheung;A. Van;Andrew Davison;Dmitry Shachnev;Miguel Molina;Simon Rothmei;Murat Bilgel;Kai Schlamp;Eduard Ort;Daniel McNamee;Jaime Arias;Dmytro Bielievtsov;Christopher J. Steele;Lijie Huang;Ivan Gonzalez;Joshua Warner;Daniel S. Margulies;Oliver Contier;Ana Marina;Victor Saase;Thomas Nickson;Jan Varada;Isaac Schwabacher;John Pellman;Nicolas Pannetier;Conor McDermottroe;Paul Glad Mihai;Krzysztof J. Gorgolewski;Satrajit S. Ghosh
  • 通讯作者:
    Satrajit S. Ghosh
The sleeping giant who left for America: Danish land inequality and emigration during the age of mass migration
那位前往美国的沉睡巨人:大众移民时代的丹麦土地不平等与移民
  • DOI:
    10.1016/j.eeh.2023.101525
  • 发表时间:
    2024-01-01
  • 期刊:
  • 影响因子:
    1.700
  • 作者:
    Nina Boberg-Fazlić;Markus Lampe;Paul Sharp
  • 通讯作者:
    Paul Sharp
North and south: long-run social mobility in England and attitudes toward welfare
  • DOI:
    10.1007/s11698-017-0160-2
  • 发表时间:
    2017-03-17
  • 期刊:
  • 影响因子:
    0.700
  • 作者:
    Nina Boberg-Fazlić;Paul Sharp
  • 通讯作者:
    Paul Sharp
806. Structural Connectomics of Affective Disturbances in Adolescence
  • DOI:
    10.1016/j.biopsych.2017.02.873
  • 发表时间:
    2017-05-15
  • 期刊:
  • 影响因子:
  • 作者:
    Paul Sharp;Eva Telzer
  • 通讯作者:
    Eva Telzer

Paul Sharp的其他文献

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{{ truncateString('Paul Sharp', 18)}}的其他基金

CROPNUT: increasing iron in cereals
CROPNUT:增加谷物中的铁含量
  • 批准号:
    BB/P017584/1
  • 财政年份:
    2018
  • 资助金额:
    $ 52.29万
  • 项目类别:
    Research Grant
The role of hepcidin in regulating intestinal iron absorption
铁调素调节肠道铁吸收的作用
  • 批准号:
    BB/D015456/1
  • 财政年份:
    2006
  • 资助金额:
    $ 52.29万
  • 项目类别:
    Research Grant
Organometallic Chemistry at the Edge of Polycyclic Aromatic Carbon Compounds
多环芳碳化合物边缘的有机金属化学
  • 批准号:
    0406353
  • 财政年份:
    2004
  • 资助金额:
    $ 52.29万
  • 项目类别:
    Continuing Grant
Organometallic Chemistry at the Edge of Polycyclic Aromatic Carbon Compounds
多环芳碳化合物边缘的有机金属化学
  • 批准号:
    0101348
  • 财政年份:
    2001
  • 资助金额:
    $ 52.29万
  • 项目类别:
    Continuing Grant

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    10108303
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