NON-INVASIVE MEASUREMENTS OF HUMAN COCHLEAR MECHANICS

人体耳蜗力学的非侵入性测量

• 批准号: 3217191
• 负责人: SUSAN J. NORTON
• 金额: $ 15.3万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3217191
• 关键词: aging; auditory stimulus; auditory threshold shift; biological signal transduction; cochlear microphonic potentials; ear hair cell; evoked potentials; hearing tests; human subject; noise biological effect; noninvasive diagnosis; psychoacoustics; sensorineural hearing loss; sound frequency; stimulus /response; visceral afferent nerve

The primary goal of the proposed research is understanding otoacoustic emissions and their relation to cochlear mechanics in normal and abnormal human ears. Otoacoustic emissions provide a direct, non-invasive measure of outer hair cell function, cochlear nonlinearities and the role of auditory efferents in cochlear function. Thus, they are a potentially powerful non-invasive research and clinical tool for assessing normal and abnormal cochlear mechanics in humans. However, several questions concerning the nature of the emission generator(s) and its relationship to cochlear status must be addressed in order to optimally interpret clinical data. Specific questions to be addressed by the proposed research include: (1) What is the nature of the emission generator ? (2) What are the relationships between transient-evoked, stimulus-frequency and combination-tone emissions ? (3) What is the role of auditory efferents in normal cochlear mechanics ? (4) How are emissions, and thus indirectly cochlear mechanics, affected by temporary threshold shift and permanent hearing loss due to noise exposure and aging in the absence of other cochlear insults ? The proposed research will provide a systematic set of data on the input-output relations among evoking stimuli and evoked emissions in large numbers of normal and abnormal ears. These data will provide a basis for better understanding the nature of cochlear hearing loss and the clinical potential of otoacoustic emissions, and serve as data for evaluating and formulating models of normal and abnormal cochlear mechanics.

拟议的研究的主要目标是了解耳声 排放及其与正常和异常的人工耳蜗的关系 人耳。耳声排放提供了直接的，无创的量度 外毛细胞功能，人工耳蜗非线性和听觉的作用 人工耳蜗功能的侵蚀。因此，它们是一个潜在的强大 用于评估正常和异常的非侵入性研究和临床工具 人的耳蜗机械师。但是，关于 排放发生器的性质及其与人工耳蜗的关系 必须解决以最佳解释临床数据。具体的 拟议的研究要解决的问题包括：（1）什么是 排放发生器的性质？ （2） 瞬态诱发的，刺激频率和组合音的排放？ （3） 听觉发出在正常的耳蜗力学中的作用是什么？ （4） 排放量如何，因此是间接的人工耳蜗的影响 由于噪音暴露而导致的暂时阈值移位和永久性听力损失 在没有其他人工耳蜗侮辱的情况下衰老？拟议的研究 将提供有关输入输出关系的系统数据集 引起大量正常和 耳朵异常。这些数据将为更好地理解 耳蜗听力损失的性质和耳声的临床潜力 排放，并用作评估和制定模型的数据 正常和异常的人工耳蜗。