SPECIFIC LANGUAGE DISORDER--GENETICS AND EPIDEMIOLOGY

特定语言障碍——遗传学和流行病学

• 批准号: 3217216
• 负责人: James Bruce Tomblin
• 金额: $ 14.46万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3217216
• 关键词: adult human (21+); child psychology; epidemiology; genetic disorder diagnosis; genetic markers; household; human population genetics; human subject; language development; language disorders; major histocompatibility complex; parent offspring interaction; speech disorder diagnosis

This proposal describes a research program designed to determine the factors that contribute to the familial aggregation of specific language disorders in families. The proposed research will identify those clinical measures necessary for the diagnosis of specific language disorders in adults. These measures will then be combined with a set of existing measures for children to determine the presence of specific language impairment (probands). Pedigrees for specific language impairment will be generated. Using these pedigrees, complex segregation analysis will be performed to determine whether there is a major genetic locus, as well as the extent to which genetic heterogeneity is present in these families showing a high density of specific language disorder. The DNA and leukocytes will be recovered from this blood for the purposes of future analysis. This research is concerned with improving our understanding of the causes of a form of developmental language disorder in which the primary manifestation is a deficit in language development in spite of apparently normal auditory sensitivity and nonverbal intelligence. By determining the basis of this familial aggregation, improved early identification, and prevention may be possible.

这份提案描述了一项研究计划，旨在确定 影响特定人群家族聚集性的因素 家庭中的语言障碍。拟议的研究将 确定诊断该病所需的临床措施 成人的特定语言障碍。届时，这些措施将 与一套针对儿童的现有措施相结合 确定是否存在特定的语言障碍(先证者)。 将生成特定语言障碍的谱系。 利用这些家系，复杂的分离分析将被 用来确定是否有一个主要的遗传位点，如 以及存在遗传异质性的程度 这些语系表现出高度密集的特定语言 无序。DNA和白细胞将从这些血液中提取出来 以供将来分析之用。 这项研究致力于提高我们对 一种发育性语言障碍的原因 主要表现形式是语言发展的缺陷，尽管 具有明显正常的听觉敏感度和非语言敏感度 智慧。通过确定这个家族的基础 聚合、改进早期识别和预防可能是 有可能。