CHEMICAL RELEASE FROM RESIN COMPOSITES INTO THE BIOPHASE

化学物质从树脂复合材料释放到生物相中

• 批准号: 3223851
• 负责人: WYATT R HUME
• 金额: $ 16.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3223851
• 关键词: acidity /alkalinity; biomaterial evaluation; biomaterial interface interaction; chemical kinetics; composite resins; cytotoxicity; dental materials; dental pulp; dentin; high performance liquid chromatography; human subject; infrared spectrometry; interferometry; tooth surface; toxicology; water solution

Dental restorative materials have the potential both for local toxicity and undesirable systemic side effects through the release of components, reaction intermediates, or degradative products into the biophase. Resin composites are a class of dental restoratives which are now very widely used. There is no evidence that any adverse systematic effects are associated with the resins. However, local effects on dental pulp, including pulpal pain and death, have been widely reported. We seek to clarify whether chemical release from the materials may contribute to these local effects. The specific aims in the project period are to quantify the release of resin composite components from a range of materials, and to seek correlation between the amounts released and the toxic effects of individual components and of aqueous eluates of whole resin samples. High performance liquid chromatography will be used to quantify the release. Variations in the pattern of release of these and other components both directly into aqueous solution and through dentin will then be determined for a number of clinically relevant variables. Concentrations of components within dentin immediately adjacent to the odontoblast layer will also be determined in teeth restored with resin composite, both in vitro and in vivo. The longterm goal is to improve safety and effectiveness of dental restorative materials. The proposed work will provide data directly relevant to the future formulation and to the clinical use of dental resin composites. It will also add to concepts and methods which will be applied to the study of other restorative materials as they are developed.

牙科修复材料具有潜在的局部毒性 以及通过释放成分而产生的不良的系统性副作用， 反应中间体或降解产物转化为生物相。树脂 复合体是目前应用非常广泛的一类牙科修复剂 使用。没有证据表明任何不利的系统性影响 与树脂有关。然而，对牙髓的局部影响， 包括牙髓疼痛和死亡，已被广泛报道。我们寻求 澄清从材料中释放的化学物质是否有助于 这些局部效应。项目期的具体目标是 量化一系列树脂复合成分的释放 材料，并寻求释放的数量与 单个组分和整体水洗脱液的毒性效应 树脂样品。高效液相色谱将用于 量化发布的数量。这些药物释放模式的变化 直接进入水溶液和通过牙本质进入的其他成分 然后将确定一些临床相关的变量。 牙本质中紧邻牙本质的成分浓度 在用树脂修复的牙齿中也将测定成牙本质细胞层 体外和体内的复合材料。长期目标是改进 牙科修复材料的安全性和有效性。建议数 工作将提供与未来制定工作直接相关的数据，并 牙科树脂复合材料的临床应用。它还将增加概念 以及将应用于其他修复剂研究的方法 材料，因为它们是显影的。