ConBioChem: Continuous bio-production of commodity chemicals

ConBioChem：大宗化学品的连续生物生产

• 批准号: BB/N023773/1
• 负责人: Alex Conradie
• 金额: $ 200.85万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN023773%2F1
• 关键词: ConBioChem; Continuous; bio; production; commodity

The current slump in oil prices should not lead us to ignore the fact that, in the future, an ever-increasing proportion of the fuels and chemicals, required for everything from jumbo jets to toy elephants, will need to come from renewable resources. This means a huge expansion of the fermentation industry, and the cost of the required manufacturing plant will rapidly become unaffordable. The solution is to move from performing fermentations batchwise (like manufacturing cars one at a time) to continuous processes (like an automobile production line). This major change presents a number of challenges in engineering production microbes, and in designing and controlling the industrial processes in which they operate. This project aims to produce a pipeline that will meet all of these challenges in an integrative manner. It will result in stable and robust production microbes in which there is an optimal balance between the growth of the process microorganism and formation of the industrial product that it generates. The new microbes will be exploited in new continuous processes, and process controls will be developed in which the microbe is 'rewarded' with nutrients for generating high levels of the industrial product. Such a 'control by incentives' strategy will, in itself, contribute to the stability of the production organism. The environmental impacts of the new processes will be assessed to ensure that they are cleaner and greener than the chemical processes that they are replacing. Lastly, the costs of building new factories to manufacture the chemicals will be assessed, together with the costs of operating them, to ensure that the new continuous bio-manufacturing processes will be profitable for UK companies.

目前油价的暴跌不应让我们忽视这样一个事实：未来，从大型喷气式飞机到玩具大象等各种产品所需的燃料和化学品中，越来越多的比例将需要来自可再生资源。这意味着发酵工业的巨大扩张，所需的制造工厂的成本将迅速变得无法负担。解决方案是从分批发酵（如一次生产一辆汽车）转向连续发酵（如汽车生产线）。这一重大变化给工程生产微生物以及设计和控制它们运行的工业过程带来了许多挑战。该项目旨在建立一个管道，以综合方式应对所有这些挑战。它将产生稳定且强大的生产微生物，其中工艺微生物的生长与其产生的工业产品的形成之间达到最佳平衡。新的微生物将在新的连续过程中被利用，过程控制将被开发，其中微生物被“奖励”以产生高水平的工业产品。这种“激励控制”战略本身将有助于生产有机体的稳定。将评估新工艺对环境的影响，以确保它们比正在取代的化学工艺更清洁、更环保。最后，将评估建造新工厂生产化学品的成本以及运营成本，以确保新的连续生物制造工艺对英国公司有利。

项目成果

Modelling, analyzing and controlling hybrid systems by Guarded Flexible Nets

通过受保护的灵活网络对混合系统进行建模、分析和控制

• 发表时间: 2019
• 期刊: Hybrid Systems
• 作者: Julez J

Probabilistic commodity price projections for unbiased techno-economic analyses

• DOI: 10.1016/j.engappai.2023.106065
• 发表时间: 2023-06
• 期刊: Eng. Appl. Artif. Intell.
• 作者: S. Rodgers;Alexander Bowler;Fanran Meng;S. Poulston;J. McKechnie;A. Conradie

Renewable butadiene: A case for hybrid processing via bio- and chemo-catalysis

可再生丁二烯：生物催化和化学催化混合加工的案例

• DOI: 10.1016/j.jclepro.2022.132614
• 发表时间: 2022
• 期刊: Journal of Cleaner Production
• 影响因子: 11.1
• 作者: Rodgers S

Steady State Analysis of Flexible Nets

柔性网络的稳态分析

• DOI: 10.1109/tac.2019.2931836
• 发表时间: 2020
• 期刊: IEEE Transactions on Automatic Control
• 影响因子: 6.8
• 作者: Julvez J

Reconciling the Sustainable Manufacturing of Commodity Chemicals with Feasible Technoeconomic Outcomes : Assessing the investment case for heat integrated aerobic gas fermentation

协调大宗化学品的可持续制造与可行的技术经济成果：评估热集成好氧气体发酵的投资案例

• DOI: 10.1595/205651321x16137377305390
• 发表时间: 2021
• 期刊: Johnson Matthey Technology Review
• 影响因子: 2.3
• 作者: Rodgers S