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HEMOGLOBIN: STRUCTURE, FUNCTION, AND GENETIC CONTROL

HEMOGLOBIN: STRUCTURE, FUNCTION, AND GENETIC CONTROL
血红蛋白：结构、功能和遗传控制
批准号：
3225887
负责人：
RICHARD T JONES
金额：
$11.59万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-09-01 至 1988-03-31
来源：
https://reporter.nih.gov/project-details/3225887
关键词：
aminoacid analyzer biochemical evolution biomedical automation cardiovascular disorder diagnosis chemical fingerprinting chemical structure function embryo /fetus death hemoglobin hemoglobin F hemoglobin Ss hemoglobinopathy hemoprotein structure human population genetics human subject hydrocephalus ion exchange chromatography molecular pathology mutant orphan disease /drug oxygen transport perinatal blood group incompatibility

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中文摘要
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本研究的目的是为了更好地理解的关系
英文摘要
The purpose of this research is to better understand the relationships of genetic control, molecular structure, and function of hemoglobins of humans and other animals. Current work includes structural characterization of abnormal human hemoglobins, sequence analysis of the zeta chain of the embryonic hemoglobin Portland 1, and comparisons of selected animal hemoglobins with those already known. Parallel studies of the functional properties of abnormal human hemoglobins are being done in order to map the functionally important residues of the molecule. Special emphasis is placed on comparisons of functional properties of mutant hemoglobins with different substitutions at the same residue position in order to better understand specific properties of functionally critical residues.
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FUNCTIONAL STUDIES OF ALTERED HEMOGLOBIN
HEMOGLOBIN: STRUCTURE, FUNCTION, AND GENETIC CONTROL
FUNCTIONAL STUDIES OF ABNORMAL HUMAN HEMOGLOBINS
FUNCTIONAL STUDIES OF ALTERED HUMAN HEMOGLOBIN
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