HEMOGLOBIN: STRUCTURE, FUNCTION, AND GENETIC CONTROL

血红蛋白：结构、功能和遗传控制

• 批准号: 3151098
• 负责人: RICHARD T JONES
• 金额: $ 12.09万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151098
• 关键词: aminoacid analyzer; biochemical evolution; biomedical automation; cardiovascular disorder diagnosis; chemical fingerprinting; chemical structure function; embryo /fetus death; hemoglobin; hemoglobin F; hemoglobin Ss; hemoglobinopathy; hemoprotein structure; human population genetics; human subject; hydrocephalus; ion exchange chromatography; molecular pathology; mutant; orphan disease /drug; oxygen transport; perinatal blood group incompatibility

The purpose of this research is to better understand the relationships of genetic control, molecular structure, and function of hemoglobins of humans and other animals. Current work includes structural characterization of abnormal human hemoglobins, sequence analysis of the zeta chain of the embryonic hemoglobin Portland 1, and comparisons of selected animal hemoglobins with those already known. Parallel studies of the functional properties of abnormal human hemoglobins are being done in order to map the functionally important residues of the molecule. Special emphasis is placed on comparisons of functional properties of mutant hemoglobins with different substitutions at the same residue position in order to better understand specific properties of functionally critical residues.

本研究的目的是为了更好地了解 人类血红蛋白的遗传控制、分子结构和功能， 其他动物。 目前的工作包括结构表征的异常 人血红蛋白，胚胎血红蛋白ζ链的序列分析 波特兰1血红蛋白，并将选定的动物血红蛋白与 已经知道了。 异常人功能特性的平行研究 血红蛋白是为了绘制功能重要的残基， 的分子。 特别强调的是比较功能 具有不同取代的突变血红蛋白的性质 残基位置，以便更好地理解特定的性质 功能关键残基。

项目成果

Recent developments in structural analysis.

结构分析的最新进展。

• 发表时间: 1980
• 期刊: Texas reports on biology and medicine
• 作者: Jones,RT

Human hemoglobin Portland II (zeta 2 beta 2). Isolation and characterization of Portland hemoglobin components and their constituent globin chains.

人血红蛋白波特兰 II（zeta 2 beta 2）。

• 发表时间: 1984
• 期刊: The Journal of biological chemistry
• 作者: Randhawa,ZI;Jones,RT;Lie-Injo,LE
• 通讯作者: Lie-Injo,LE

Hemoglobin Columbia Missouri or alpha 2[88 (F9) Ala----Val]beta 2: a new high-oxygen-affinity hemoglobin that causes erythrocytosis.

哥伦比亚密苏里血红蛋白或 α 2[88 (F9) Ala----Val]beta 2：一种新的高氧亲和力血红蛋白，可导致红细胞增多。

• DOI: 10.1016/s0025-6196(12)61169-0
• 发表时间: 1991
• 期刊: Mayo Clinic proceedings
• 影响因子: 8.9
• 作者: Perry,MC;Head,C;Fairbanks,VF;Jones,RT;Taylor,H;Proud,V
• 通讯作者: Proud,V

Separation of zeta (zeta) and various gamma (gamma) chains of human embryonic hemoglobin Portland I by reverse-phase high-performance liquid chromatography.

采用反相高效液相色谱法分离人胚胎血红蛋白 Portland I 的 zeta（zeta）和各种 γ（gamma）链。

• DOI: 10.1016/0003-2697(83)90067-2
• 发表时间: 1983
• 期刊: Analytical biochemistry
• 影响因子: 2.9
• 作者: Randhawa,ZI;Jones,RT;Lie-Injo,LE
• 通讯作者: Lie-Injo,LE

Separation of the tryptic peptides and cyanogen bromide fragments of the human embryonic zeta chains of hemoglobin in Portland I and II by reverse phase high performance liquid chromatography.

通过反相高效液相色谱分离波特兰 I 和 II 中人胚胎血红蛋白 zeta 链的胰蛋白酶肽和溴化氰片段。

• DOI: 10.3109/03630268408991732
• 发表时间: 1984
• 期刊: Hemoglobin
• 影响因子: 1
• 作者: Randhawat,ZI;Jones,RT;Lie-Injo,LE
• 通讯作者: Lie-Injo,LE