HEMOGLOBIN: STRUCTURE, FUNCTION, AND GENETIC CONTROL

本研究的目的是为了更好地了解 人类血红蛋白的遗传控制、分子结构和功能， 其他动物。 目前的工作包括结构表征的异常 人血红蛋白，胚胎血红蛋白ζ链的序列分析 波特兰1血红蛋白，并将选定的动物血红蛋白与 已经知道了。 异常人功能特性的平行研究 血红蛋白是为了绘制功能重要的残基， 的分子。 特别强调的是比较功能 具有不同取代的突变血红蛋白的性质 残基位置，以便更好地理解特定的性质 功能关键残基。

The purpose of this research is to better understand the relationships of genetic control, molecular structure, and function of hemoglobins of humans and other animals. Current work includes structural characterization of abnormal human hemoglobins, sequence analysis of the zeta chain of the embryonic hemoglobin Portland 1, and comparisons of selected animal hemoglobins with those already known. Parallel studies of the functional properties of abnormal human hemoglobins are being done in order to map the functionally important residues of the molecule. Special emphasis is placed on comparisons of functional properties of mutant hemoglobins with different substitutions at the same residue position in order to better understand specific properties of functionally critical residues.