Brassica Rapeseed And Vegetable Optimisation

甘蓝型油菜籽和蔬菜优化

• 批准号: BB/P003095/1
• 负责人: Lars Ostergaard
• 金额: $ 447.78万
• 依托单位: John Innes Centre
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP003095%2F1
• 关键词: Brassica; Rapeseed; Vegetable; Optimisation

Agriculture is facing the crucial challenge of adapting crop productivity to changes in the climate. More variable weather patterns require the development of crops that are able to perform more robustly under a wider range of environmental conditions. At the same time, climate change also provides new opportunities for increasing the length of the UK vegetable growing season and increasing food security by reducing imports of fresh produce during the winter, but this requires breeding new varieties that are able to produce robustly at different times of year.The BRAVO consortium aims to meet these challenges through close interactions between academia and industry. To achieve this goal, we have brought together world-leading experts in both Arabidopsis and Brassica plant reproduction from research institutes and universities within the UK. As the result of a series of meetings between consortium members and stakeholders from the oilseed rape and vegetable Brassica industries, optimisation of flowering and coordination of developmental transitions in the production of high-quality seeds were identified as important common targets. These transitions that occur during plant reproduction such as to flowering, fertilisation, inflorescence growth, seed production, dispersal, and subsequent seed performance are now known to be managed by environmentally responsive gene networks built on a foundation of common components first described for their ability to control flowering time.The goal of BRAVO is to provide a mechanistic understanding of the role of flowering time gene networks in the control of Brassica reproductive developmental transitions from vegetative growth through to seed production and seed vigour. Because these networks control environmental responsiveness, this knowledge can be exploited to increase robustness in the performance of oilseed and vegetable Brassicas. A key challenge is how to optimise individual traits when the same flowering time gene network has been optimised by evolution over millions of years for multiple functions, each of which is important for crop performance. In this proposal, we will combine genomics and phenomics technologies with approaches in developmental genetics and mathematical modelling to link genotype to phenotype for master regulators of key transitions during Brassica reproductive development. Through exploitation of available genetic resources, we will reveal the architecture of flowering time gene networks in Brassicas and how they have been modified in the past by plant breeders to cause trait variation, life history variation and climate adaptation. This will allow us to develop a predictive framework for designing strategies to vary specific crop characteristics without harming others, and to generate and test novel genetic variation with potential uses in future trait enhancement.In parallel we will establish and exploit resources such as a gene expression atlas and targeted gene disruption which will allow the Brassica research and breeding communities to expand knowledge on important biological processes and use the outputs form BRAVO collectively to improve Brassica crop performance. Long-term improved and sustainable Brassica crop performance can only be achieved through fundamental understanding of biological processes. The composition of the BRAVO consortium allows the combination of excellence in Brassica research with knowledge transfer from the closely related Arabidopsis model species. The project builds on and expands academia-industry interactions through industrial membership on the project's Supervisory Board, industry engagement and practical involvement in case studies, frequent consortium meetings and annual stakeholder events.We believe this project provides a unique opportunity to align industry priorities with excellent fundamental research programmes in order to help secure the future yield of Brassica crops in the UK and worldwide.

农业正面临着使作物产量适应气候变化的重大挑战。更多变的天气模式需要开发能够在更广泛的环境条件下表现更强劲的作物。与此同时，气候变化也为延长英国蔬菜生长季节和通过减少冬季新鲜农产品进口来提高粮食安全提供了新的机遇，但这需要培育能够在一年中不同时间生产的新品种。BRAVO联盟旨在通过学术界和工业界之间的密切互动来应对这些挑战。为了实现这一目标，我们汇集了来自英国研究机构和大学的世界领先的拟南芥和芸苔属植物繁殖专家。作为联合体成员与油菜和蔬菜芸苔业利益攸关方之间一系列会议的结果，优化开花和协调高质量种子生产的发展过渡被确定为重要的共同目标。这些转变发生在植物繁殖过程中，如开花、受精、花序生长、种子生产、传播，和随后的种子性能现在已知是由环境响应基因网络管理的，所述基因网络建立在首先描述其控制开花时间的能力的共同组分的基础上。BRAVO的目标是提供对开花时间基因网络在开花时间中的作用的机理理解。控制芸苔属植物从营养生长到种子生产和种子活力的生殖发育转变。由于这些网络控制着环境响应性，因此可以利用这些知识来提高油籽和蔬菜作物性能的稳健性。一个关键的挑战是如何优化个体性状，因为同一开花时间的基因网络已经通过数百万年的进化优化了多种功能，其中每一种功能对作物表现都很重要。在这个提议中，我们将联合收割机基因组学和表型学技术与发育遗传学和数学建模的方法相结合，将基因型与表型联系起来，为芸苔属植物生殖发育过程中关键转变的主调节器。通过利用现有的遗传资源，我们将揭示开花时间基因网络的结构，以及它们在过去是如何被植物育种者修改，从而导致性状变异、生活史变异和气候适应的。这将使我们能够开发一个预测框架，用于设计策略，以改变特定的作物特性，而不伤害其他作物，同时，我们将建立和开发基因表达图谱和靶向基因破坏等资源，这将使芸苔属研究和育种界能够扩展重要生物学过程的知识，共同使用BRAVO的输出来提高芸苔属作物的性能。只有通过对生物学过程的基本理解，才能实现长期改善和可持续的芸苔属作物表现。BRAVO财团的组成允许将芸苔属研究的卓越性与密切相关的拟南芥模式物种的知识转移相结合。该项目建立并扩大了芸苔属植物与产业的互动，通过该项目监事会的产业成员资格，产业参与和实际参与案例研究，频繁的联盟会议和年度利益相关者活动。我们相信，该项目提供了一个独特的机会，将产业优先事项与优秀的基础研究计划结合起来，以帮助确保英国和全球芸苔属植物作物的未来产量。

项目成果

Additional file 1 of The oilseed rape developmental expression resource: a resource for the investigation of gene expression dynamics during the floral transition in oilseed rape

油菜发育表达资源的附加文件 1：用于研究油菜花转变期间基因表达动态的资源

• DOI: 10.6084/m9.figshare.12687131
• 发表时间: 2020
• 作者: D. Marc Jones

Comparative transcriptomics reveals desynchronisation of gene expression during the floral transition between Arabidopsis and Brassica rapa cultivars.

• DOI: 10.1017/qpb.2021.6
• 发表时间: 2021
• 期刊: Quantitative plant biology
• 作者: Calderwood, Alexander;Hepworth, Jo;Woodhouse, Shannon;Bilham, Lorelei;Jones, D. Marc;Tudor, Eleri;Ali, Mubarak;Dean, Caroline;Wells, Rachel;Irwin, Judith A.;Morris, Richard J.
• 通讯作者: Morris, Richard J.

Bayesian optimisation for yield in high-dimensional trait-space identifies crop ideotypes in Oil Seed Rape

• DOI: 10.1101/2021.07.19.452946
• 发表时间: 2021-07
• 期刊: bioRxiv
• 作者: A. Calderwood;L. Siles;P. Eastmond;S. Kurup;R. Morris

Automated extraction of pod phenotype data from micro-computed tomography.

• DOI: 10.3389/fpls.2023.1120182
• 发表时间: 2023
• 期刊: Frontiers in plant science
• 影响因子: 5.6

Total FLC transcript dynamics from divergent paralogue expression explains flowering diversity in Brassica napus.

• DOI: 10.1111/nph.17131
• 发表时间: 2021-03
• 期刊: The New phytologist
• 作者: Calderwood A;Lloyd A;Hepworth J;Tudor EH;Jones DM;Woodhouse S;Bilham L;Chinoy C;Williams K;Corke F;Doonan JH;Ostergaard L;Irwin JA;Wells R;Morris RJ
• 通讯作者: Morris RJ