METABOLISM OF THE DEVELOPING SMALL INTESTINE

发育中的小肠的新陈代谢

• 批准号: 3228396
• 负责人: OTAKAR KOLDOVSKY
• 金额: $ 21.61万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-01-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3228396
• 关键词: breast feeding; developmental nutrition; diet; epidermal growth factor; gastrointestinal infection; growth /development; hormone receptor; hormone regulation /control mechanism; ileum; immunochemistry; intestinal villi; jejunum; laboratory rat; milk; nutrition related tag; perinatal; prolactin; protein biosynthesis; radiotracer; small intestines; weanling animal

Breast milk contains hormones of peptide character, but very little is known about their role in suckling neonates. The importance of this question is stressed by the fact that many of these hormones are not detectable in infant feeding formulas. The purpose of the present application is to evaluate (using suckling and weanling rats as the experimental mode) gastrointestinal processing of epidermal growth factor and prolactin, the routes of absorption (portal blood vs absorption via lymphatics), as well as delivery and metabolism of orally-absorbed epidermal growth factor and prolactin in selected target organs (i.e., brain, liver lung, skin). The role of the presence of epidermal growth factor and prolactin in milk will be tested further by following development of the gastrointestinal tract and other organs of sucklings by feeding formulas containing known amounts of epidermal growth factor and/or absorption. Finally, the cytoprotective role of epidermal growth factor and prolactin will be tested in an experimental model of necrotizing enterocolitis.

母乳包含肽特征的激素，但很少 知道他们在哺乳新生儿中的作用。 重要性 这些激素中的许多人都强调了这个问题 在婴儿喂养公式中无法检测到。 目的 目前的应用是评估（使用哺乳和断奶 大鼠作为实验模式）的胃肠道处理 表皮生长因子和催乳素，吸收途径 （通过淋巴管吸收门户血液与吸收）以及递送 以及口服表皮生长因子的代谢和 选定靶器官（即脑，肝肺， 皮肤）。 表皮生长因子和催乳素的存在的作用 在牛奶中，将通过遵循的开发来进一步测试 胃肠道和其他吮吸器官通过进食 包含已知量表皮生长因子和/或的公式 吸收。 最后，表皮生长因子的细胞保护作用和 催乳素将在坏死的实验模型中进行测试 小肠结肠炎。