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HLA AND TRANSPLANTATION

HLA AND TRANSPLANTATION
HLA 和移植
批准号：
3224353
负责人：
PAUL I TERASAKI
金额：
$11.48万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
项目状态：
已结题
起止时间：
1976-12-01 至 1991-12-31
来源：
https://reporter.nih.gov/project-details/3224353
关键词：
African American B lymphocyte Graves disease antileukocyte isoantibody autoimmune disorder congenital disorders genetic markers homologous transplantation human population genetics human tissue immunochemistry immunogenetics kidney transplantation lymphomatous thyroiditis multiple sclerosis racial /ethnic difference transplantation resource /registry /referral center

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中文摘要
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英文摘要
The primary aim of this project will be continued study of the allograft problem. Studies of factors influencing transplant survival will utilize an extensive data base collected over the past 12 years and analyses will be done using an on-site computer facility. Factors to be examined include HLA-DR histocompatibility matching, possible enhancing antibodies, and the transfusion effect. Efforts will be made to devise means by which enhancing antibodies induced by transfusiuons can be detected. Sera from patients who subsequently reject grafts will be compared to those with successful grafts. Antimmunoglobulin antibodies are the principal antibodies postulated to be enhancing antibodies.
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