Modulation of T-/B-lymphocyte immigration affects subsequent allograft damage (B06)

T/B 淋巴细胞迁移的调节会影响随后的同种异体移植物损伤 (B06)

• 批准号: 517500221
• 金额: --
• 依托单位: Abteilung für Nephrologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/517500221?language=en
• 关键词: Modulation; lymphocyte; immigration; affects; subsequent

Due to the clinical need for sustainable treatment of antibody-mediated rejection and the pivotal role of B cells in this context, we will move forward with our well-characterized renal transplantation (RTx) model in rats. We plan to investigate the synergistic effects of a T-cell depleting and anti-BAFF receptor therapy for prevention of rejection in pre-immunized recipients as well as on the secretion of Dickkopf 3 (DKK3), which has been recently characterized regarding its relevance in transplantation medicine. As a perspective, we want to examine the effects of DKK3 silencing in an experimental RTx model with regard to prevention of development of interstitial fibrosis and tubular atrophy.

由于抗体介导的排斥反应的可持续治疗的临床需求和B细胞在此背景下的关键作用，我们将继续我们的良好表征的大鼠肾移植（RTx）模型。我们计划研究T细胞耗竭和抗BAFF受体治疗对预防预免疫受者排斥反应以及对Dickkopf 3（DKK 3）分泌的协同作用，DKK 3最近已被表征为与移植医学相关。作为一种观点，我们想要检查DKK 3沉默在实验RTx模型中关于预防间质纤维化和肾小管萎缩的发展的作用。