THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
批准号:
3229080
负责人:
ALAN M WEINSTEIN
金额:
$10.1万
依托单位国家:
美国
项目类别:
财政年份:
1981
资助国家:
美国
项目状态:
已结题
起止时间:
1981-08-01 至 1993-01-31
关键词:
biological fluid transport carbonates chloride channels computer simulation epithelium gallbladder glucose transport hydrogen channel ionophores mathematical model membrane permeability membrane potentials micropuncture osmosis phosphates potassium channel renal tubular transport sodium channel solute urea water
中文摘要
数学模型被公式化,其将上皮表示为系统
隔室和边界膜,并允许计算机模拟
正常和病理状态。 该项目还承担了
分析简化的、近似的数学模型,
对实验数据的解释。 近似值的比较
分析模型与详细的计算机模拟是用来评估
较简单模型的适用范围。 的主要目标是
下一个调查阶段是完成近端模型
肾血管单位-包括近端小管、肾小球和
管周毛细血管 该模型跟踪的浓度和通量
Na+、K+、H+、Cl-、碳酸根离子、二级磷酸氢根离子、初级
磷酸氢根离子、葡萄糖和尿素。 一进程的主要重点
模拟是近端小管钠重吸收的研究:
钠转运的跨上皮途径和驱动力,
物理因素调节这种重吸收的机制。 在
特别是,这是一个努力量化的影响,流明和
调节肾小球滤过平衡的管周因子
和近端重吸收。 第二个焦点是
近曲小管重吸收:转运机制的确定
在细胞膜系统中,
模型,在模拟酸碱紊乱。 特别
感兴趣的是近端肾单位在维持肾功能中的作用。
代谢性肾小球硬化-定义肾小球减少的相互作用
滤过率、细胞外容量耗竭和肾小管周围增加
博士 下一个研究期的第二个目标是代表性
皮质集合小管的一部分 该模型将以
从蟾蜍和乌龟膀胱的模拟逐步的方式。 它
将用于探索肾小管流动,酸碱状态,
和钠亲合力对肾单位段钾转运的影响。
英文摘要
Mathematical models are formulated that represent an epithelium as a system
of compartments and bounding membranes and permit the computer simulation
of normal and pathological states. This project also undertakes the
analysis of simplified, approximate, mathematical models, which may be used
in the interpretation of experimental data. Comparison of the approximate
analytical models with the detailed computer simulation is used to assess
the range of applicability of the simpler models. The major aim for the
next period of investigation is the completion of a model of the proximal
nephrovascular unit - including proximal tubule, glomerulus, and
peritubular capillary. The model tracks the concentrations and fluxes of
Na+, K+, H+, Cl-, carbonate ion, secondary hydrogen phosphate ion, primary
hydrogen phosphate ion, glucose and urea. The primary focus of this
simulation is the study of the proximal tubule sodium reabsorption: the
transepithelial pathways and driving forces of sodium transport and the
mechanisms by which physical factors modulate this reabsorption. In
particular, this is an effort to quantify the effects of luminal and
peritubular factors which mediate the balance between glomerular filtration
and proximal reabsorption. The second focus is the representation of
proximal tubule bicarbonate reabsorption: mechanisms of transport defined
in cell membrane systems are to be examined in the context of a tubule
model, in simulations of the acid-base disturbances. Of particular
interest is the role of the proximal nephron in the maintenance of
metabolic alkalosis - defining the interplay of decreased glomerular
filtration rate, extracellular volume depletion, and increased peritubular
pH. A second aim for the next investigational period is the representation
of the cortical collecting tubule. This model will be developed in a
step-wise fashion from simulations of toad and turtle urinary bladder. It
will be used to explore the interaction of tubule flow, acid-base states,
and sodium avidity on potassium transport by this nephron segment.
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Theory of Solute and Water Transport Across Epithelia
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资助金额:$7.43万
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批准号:6370103
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资助金额:$16.42万
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Theory of Solute and Water Transport Across Epithelia
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批准号:7142397
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资助金额:$22.71万
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依托单位:
Theory of Solute and Water Transport Across Epithelia
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资助金额:$21.19万
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负责人:ALAN M WEINSTEIN
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依托单位:
Theory of Solute and Water Transport Across Epithelia
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批准号:7250102
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资助金额:$20.06万
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Theory of Solute and Water Transport Across Epithelia
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资助金额:$21.28万
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Theory of Solute and Water Transport Across Epithelia
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资助金额:$18.0万
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负责人:ALAN M WEINSTEIN
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依托单位:
THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
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THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
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负责人:ALAN M WEINSTEIN
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依托单位:
THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
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批准号:2138244
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THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
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批准号:3229076
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负责人:ALAN M WEINSTEIN
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财政年份:1981
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负责人:ALAN M WEINSTEIN
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批准号:6699911
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项目类别:
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资助金额:$21.19万
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财政年份:1981
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负责人:ALAN M WEINSTEIN
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依托单位:
Theory of Solute and Water Transport Across Epithelia
-
批准号:6846602
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项目类别:
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资助金额:$21.19万
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财政年份:1981
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负责人:ALAN M WEINSTEIN
-
依托单位:
海外基金