INTESTINAL LIPOPROTEIN METABOLISM
INTESTINAL LIPOPROTEIN METABOLISM
批准号:
3235144
负责人:
ALLEN COOPER
金额:
$16.04万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-08-01 至 1992-07-31
关键词:
HMG coA reductases Pongidae apolipoproteins atherosclerosis blood lipoprotein metabolism cholesterol dietary lipid enzyme mechanism gastrointestinal neoplasms high density lipoproteins histochemistry /cytochemistry human tissue intestines laboratory mouse laboratory rabbit laboratory rat liver circulation low density lipoprotein nucleic acid probes receptor species difference
中文摘要
在本申请中,我们建议研究以下几个方面
肠道脂蛋白代谢。首先,我们将评估到In
肠的不同部分在肠道中的作用
低密度脂蛋白(LDL)的降解。的一个独特的方面
这项工作将利用抗受体抗体来研究低密度脂蛋白
新陈代谢。受体沿胃肠道的分布将
通过免疫组织化学和直接结合的方法确定。这个
隐窝和绒毛细胞及亚细胞中受体的存在
受体的位置也将被确定。规管
血药浓度变化对受体数量的影响及意义
还将研究饮食和药物方面的干扰以及
癌变对受体数量的影响。
在其他研究中,低密度脂蛋白受体在高密度脂蛋白中的作用
将对脂蛋白代谢进行研究。问题是,是否
有超过载脂蛋白的胆固醇的运输
地址。
英文摘要
In this application, we propose to study several aspects of
intestinal lipoprotein metabolism. First, we will evaluate to in
depth the role of the various parts of the intestine in the
degradation of low density lipoprotein (LDL). A unique aspect of
this work will be the use of antireceptor antibodies to study LDL
metabolism. The distribution of receptors along the GI tract will
be determined by immunohistochemistry and direct binding. The
presence of receptors in crypt and villous cells and the subcellular
location of the receptors will also be determined. Regulation of
receptor number under the influence of altered serum level and
dietary and pharmacologic perturbation will be studied as well as
the effect of malignant degeneration on receptor number.
In other studies, the role of the LDL receptor in high density
lipoprotein metabolism will be studied. The question of whether
there is transport of cholesterol in excess of apoprotein will be
addressed.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CORE--TRANSGENIC ANIMAL FACILITY
-
批准号:6105375
-
项目类别:
-
资助金额:$2.4万
-
财政年份:1996
-
负责人:ALLEN COOPER
-
依托单位:
CORE--TRANSGENIC ANIMAL FACILITY
-
批准号:6296460
-
项目类别:
-
资助金额:$2.4万
-
财政年份:1996
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:2073637
-
项目类别:
-
资助金额:$1.58万
-
财政年份:1994
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3523001
-
项目类别:
-
资助金额:$2.75万
-
财政年份:1993
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3522959
-
项目类别:
-
资助金额:$2.61万
-
财政年份:1992
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3522917
-
项目类别:
-
资助金额:$1.17万
-
财政年份:1991
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3525565
-
项目类别:
-
资助金额:$1.28万
-
财政年份:1990
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION PROGRAM
-
批准号:3525454
-
项目类别:
-
资助金额:$1.32万
-
财政年份:1989
-
负责人:ALLEN COOPER
-
依托单位:
SMALL INSTRUMENTATION PROGRAM
-
批准号:3525355
-
项目类别:
-
资助金额:$1.26万
-
财政年份:1988
-
负责人:ALLEN COOPER
-
依托单位:
ELUTRIATOR ROTOR, BENCH TOP FREEZE DRYER
-
批准号:3523961
-
项目类别:
-
资助金额:$0.91万
-
财政年份:1987
-
负责人:ALLEN COOPER
-
依托单位:
INTESTINAL LIPOPROTEIN METABOLISM
-
批准号:3235143
-
项目类别:
-
资助金额:$16.53万
-
财政年份:1987
-
负责人:ALLEN COOPER
-
依托单位:
INTESTINAL LIPOPROTEIN METABOLISM
-
批准号:3235139
-
项目类别:
-
资助金额:$16.68万
-
财政年份:1987
-
负责人:ALLEN COOPER
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT
-
批准号:3515531
-
项目类别:
-
资助金额:$4.5万
-
财政年份:1987
-
负责人:ALLEN COOPER
-
依托单位:
INTESTINAL LIPOPROTEIN METABOLISM
-
批准号:3235141
-
项目类别:
-
资助金额:$16.68万
-
财政年份:1987
-
负责人:ALLEN COOPER
-
依托单位:
INTESTINAL LIPOPROTEIN METABOLISM
-
批准号:3235142
-
项目类别:
-
资助金额:$17.31万
-
财政年份:1987
-
负责人:ALLEN COOPER
-
依托单位:
HEPATIC METABOLISM OF DIET DERIVED LIPOPROTIENS
-
批准号:6329339
-
项目类别:
-
资助金额:$42.82万
-
财政年份:1986
-
负责人:ALLEN COOPER
-
依托单位:
HEPATIC METABOLISM OF DIET DERIVED LIPOPROTEINS
-
批准号:2140461
-
项目类别:
-
资助金额:$35.1万
-
财政年份:1986
-
负责人:ALLEN COOPER
-
依托单位:
HEPATIC METABOLISM OF DIET DERIVED LIPOPROTEINS
-
批准号:2140462
-
项目类别:
-
资助金额:$36.92万
-
财政年份:1986
-
负责人:ALLEN COOPER
-
依托单位:
HEPATIC METABOLISM OF DIET DERIVED LIPOPROTIENS
-
批准号:2751553
-
项目类别:
-
资助金额:$42.13万
-
财政年份:1986
-
负责人:ALLEN COOPER
-
依托单位:
HEPATIC METABOLISM OF DIET DERIVED LIPOPROTEINS
-
批准号:3237621
-
项目类别:
-
资助金额:$32.67万
-
财政年份:1986
-
负责人:ALLEN COOPER
-
依托单位: