HDHL-Biomarkers: VALID, Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older adults

HDHL-生物标志物：有效，戊内酯和健康老龄化：将饮食、生物标志物和代谢健康与老年人的认知联系起来

• 批准号: BB/P028225/1
• 负责人: Helene McNulty
• 金额: $ 23.31万
• 依托单位: University of Ulster
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP028225%2F1
• 关键词: HDHL; Biomarkers; VALID; Valerolactones; healthy

Globally, populations are ageing; by 2050 it is estimated that more than 2 billion people will be aged over 60 years. This will be accompanied by an increase in cognitive dysfunction which ranges from mild cognitive impairment to dementia. Certain dietary patterns or nutritional components may have a beneficial role, thus offering potential strategies to prevent or delay the onset of cognitive dysfunction in ageing. (Poly)phenols are one such category, but linking these to cognition and other health outcomes is difficult because they appear in the blood for only a brief period of time (2-4 hours) after consumption of fruits and vegetables, which then limits the development of good blood based biomarkers of dietary consumption as a result. Our study will address this problem; procyanidins commonly found in foods such as tea, cocoa, grapes, nuts and berries, are of specific interest among (poly)phenols, and are almost exclusively broken down by gut bacteria to phenolic acids and valerolactones. These valerolactones are thought to be beneficial to health and have the added advantage that they remain in the blood for longer periods of time (up to 48 hours), thus offering new blood based biomarker(s) to detect dietary consumption of foods such as tea, cocoa, grapes, nuts and berries. In our project we aim to validate gamma-valerolactones as stable blood biomarkers of foods such as tea, cocoa, grapes, nuts and berries and demonstrate their association with markers of inflammation and metabolic health, and ultimately cognitive function, in an ageing European population. To do this, we will utilise data and perform new analysis on samples from the Trinity, Ulster, Department of Agriculture Study (TUDA) cohort study, a unique resource designed to assess nutrition and ageing in 5,186 adults aged 60-102 years recruited from the island of Ireland, and including a range of existing biomarkers, metabolic health status and cognitive measures. In this way, our project will identify and validate gamma-valerolactones as novel biomarkers that are modulated by dietary (poly)phenols and associated with favourable health outcomes in ageing.

在全球范围内，人口正在老龄化;到2050年，估计将有20多亿人超过60岁。这将伴随着认知功能障碍的增加，从轻度认知障碍到痴呆症。某些饮食模式或营养成分可能具有有益的作用，从而提供了预防或延迟衰老中认知功能障碍发作的潜在策略。（多酚）就是这样的一类，但将这些与认知和其他健康结果联系起来是困难的，因为它们在食用水果和蔬菜后仅在血液中出现很短的时间（2-4小时），这限制了基于良好血液的饮食消费生物标志物的发展。我们的研究将解决这个问题;原花青素通常存在于茶，可可，葡萄，坚果和浆果等食物中，是（多）酚类中特别感兴趣的，并且几乎完全被肠道细菌分解为酚酸和戊内酯。这些戊内酯被认为对健康有益，并且具有额外的优势，即它们在血液中保留更长的时间（长达48小时），从而提供新的基于血液的生物标志物来检测食物如茶，可可，葡萄，坚果和浆果的饮食消费。在我们的项目中，我们的目标是验证γ-戊内酯作为茶，可可，葡萄，坚果和浆果等食物的稳定血液生物标志物，并证明它们与炎症和代谢健康标志物以及最终认知功能的相关性。为此，我们将利用数据并对来自阿尔斯特Trinity农业部研究（TUDA）队列研究的样本进行新的分析，这是一项独特的资源，旨在评估从爱尔兰岛招募的5，186名60-102岁成年人的营养和衰老，包括一系列现有的生物标志物，代谢健康状况和认知措施。通过这种方式，我们的项目将识别和验证γ-戊内酯作为新型生物标志物，这些生物标志物受饮食（多酚）调节，并与衰老中的有利健康结果相关。

项目成果

Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.

• DOI: 10.1002/gps.5771
• 发表时间: 2022-07
• 期刊: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 4
• 作者: Dyer, Adam H.;Laird, Eamon;Hoey, Leane;Hughes, Catherine F.;McNulty, Helene;Ward, Mary;Strain, J. J.;O'Kane, Maurice;Tracey, Fergal;Molloy, Anne M.;Cunningham, Conal;Sexton, Donal J.;McCarroll, Kevin
• 通讯作者: McCarroll, Kevin

Valerolactones and healthy Ageing: Linking Dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults - The VALID Project

戊内酯和健康老龄化：将饮食因素、营养生物标志物、代谢状态和炎症与老年人的认知联系起来 - The VALID Project

• DOI: 10.1016/j.numecd.2019.05.017
• 发表时间: 2019
• 期刊: Nutrition, Metabolism and Cardiovascular Diseases
• 作者: Angelino D

Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study

低度全身炎症与老年人特定领域的认知表现和认知能力下降有关：TUDA 研究的数据

• DOI: 10.1016/j.neurobiolaging.2023.11.008
• 期刊: Neurobiology of Aging
• 影响因子: 4.2
• 作者: Dyer A.H.

A holistic approach to healthy ageing: how can people live longer, healthier lives?

• DOI: 10.1111/jhn.12566
• 发表时间: 2018-08-01
• 期刊: JOURNAL OF HUMAN NUTRITION AND DIETETICS
• 影响因子: 3.3
• 作者: Calder, P. C.;Carding, S. R.;McNulty, H.
• 通讯作者: McNulty, H.