Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.
Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.
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在社区居住的老年人中，肾功能下降与较差的领域特定认知表现有关。
DOI：
10.1002/gps.5771
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发表时间：
2022-07
影响因子：
4
通讯作者：
McCarroll, Kevin
中科院分区：
文献类型：
--
作者：
Dyer, Adam H.;Laird, Eamon;Hoey, Leane;Hughes, Catherine F.;McNulty, Helene;Ward, Mary;Strain, J. J.;O'Kane, Maurice;Tracey, Fergal;Molloy, Anne M.;Cunningham, Conal;Sexton, Donal J.;McCarroll, Kevin
虽然慢性肾脏疾病与认知障碍有关，但估计肾小球滤过率(EGFR)降低与特定领域认知能力之间的联系不太清楚，可能代表着促进老年人最佳大脑健康的一个重要目标。来自三一阿尔斯特农业部的60岁的参与者接受了详细的认知评估，使用了简易精神状态检查(MMSE)、正面评估成套测验(FAB)和可重复成套神经心理状态评估成套工具(RBANS)。泊松和线性回归模型评估了EGFR层级和认知表现之间的关系。在4887名老年人(73.9±88.3岁；67.7%女性)中，EGFR水平下降与MMSE/FAB错误的可能性更大以及RBANS的整体表现更差相关。经稳健的协变量调整后，GFR<；45g/ml/1.73m~2的结果最好(发病率比：1.17；95%CI 1.08，1.27；p<；0.001；β：−：1.13；95%CI 1.04，1.13；p<；0.001；FAb；β：−3.66；95%CI−5.64，−1.86；p<；0.001。此外，EGFR<；45毫升/毫升/1.73毫升/平方英尺与所有五个RBANS领域的表现较差有关，对即时记忆、延迟记忆和注意力的影响最大。在60-70岁的人群中关联性最强，而在80岁的人群中没有观察到关联性。肾功能降低与较差的整体和特定领域的神经心理表现有关。EGFR<；45亿毫升/分钟/1.73百万平方米与60-70岁人群的相关性最强，这表明这一人群可能会从旨在促进老年人最佳大脑健康的潜在多领域干预中受益。肾功能降低与老年人在整体和领域特定认知功能测试中的表现较差有关。特别是，老年人的肾功能下降与在即刻记忆、延迟记忆和注意力测试中表现较差有关。相关性在60-70岁的人和那些估计肾小球滤过率(EGFR)和45亿毫升/分钟/1.73百万米2的人中最强。
Whilst chronic kidney disease has been associated with cognitive impairment, the association between reduced estimated Glomerular Filtration Rate (eGFR) and domain‐specific cognitive performance is less clear and may represent an important target for the promotion of optimal brain health in older adults. Participants aged >60 years from the Trinity‐Ulster‐Department of Agriculture study underwent detailed cognitive assessment using the Mini‐Mental State Examination (Mini‐Mental State Examination (MMSE)), Frontal Assessment Battery (FAB) and Repeatable Battery for Assessment of Neuropsychological Status (RBANS). Poisson and linear regression models assessed the relationship between eGFR strata and cognitive performance. In 4887 older adults (73.9 ± 8.3 years; 67.7% female), declining eGFR strata was associated with greater likelihood of error on the MMSE/FAB and poorer overall performance on the RBANS. Following robust covariate adjustment, findings were greatest for GFR <45 ml/ml/1.73 m2 (Incidence Rate Ratio: 1.17; 95% CI 1.08, 1.27; p < 0.001 for MMSE; IRR: 1.13; 95% CI 1.04, 1.13; p < 0.001 for FAB; β: −3.66; 95% CI −5.64, −1.86; p < 0.001 for RBANS). Additionally, eGFR <45 ml/ml/1.73 m2 was associated with poorer performance on all five RBANS domains, with greatest effect sizes for immediate memory, delayed memory and attention. Associations were strongest in those aged 60–70, with no associations observed in those >80 years. Reduced kidney function was associated with poorer global and domain‐specific neuropsychological performance. Associations were strongest with eGFR <45 ml/min/1.73 m2 and in those aged 60–70 years, suggesting that this population may potentially benefit from potential multi‐domain interventions aimed at promoting optimal brain health in older adults. Reduced kidney function was associated with poorer performance on tests of global and domain‐specific cognitive function in older adults. In particular, reduced kidney function in older adults was associated with poorer performance in tests of immediate memory, delayed memory and attention. Associations were strongest in those aged 60–70 years and in those with estimated Glomerular Filtration Rate (eGFR) <45 ml/min/1.73 m2.
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影响因子：
4.1
作者：
Legdeur N;Heymans MW;Comijs HC;Huisman M;Maier AB;Visser PJ
通讯作者：
Visser PJ
DOI：
10.1111/j.1532-5415.2012.04043.x
发表时间：
2012-07-01
影响因子：
6.3
作者：
Feng, Liang;Yap, Keng Bee;Tze Pin Ng
通讯作者：
Tze Pin Ng
DOI：
10.1093/ndt/gfab182
发表时间：
2021-07-23
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Paterson EN;Maxwell AP;Kee F;Cruise S;Young IS;McGuinness B;McKay GJ
通讯作者：
McKay GJ
DOI：
10.1016/j.jamda.2018.11.031
发表时间：
2019-05-01
影响因子：
7.6
作者：
Moore, Katie;Hughes, Catherine F.;McNulty, Helene
通讯作者：
McNulty, Helene
影响因子：
6.1
作者：
Etgen, Thorleif;Sander, Dirk;Bickel, Horst
通讯作者：
Bickel, Horst