DERIVE:Dev. of Riboflavin biomarkers to relate dietary sources with status, gene-nutrient interactions and validated health effects in adult cohorts

派生：开发。

• 批准号: BB/P028241/1
• 负责人: Mary Ward
• 金额: $ 26.44万
• 依托单位: University of Ulster
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP028241%2F1
• 关键词: DERIVE; Dev.; Riboflavin; biomarkers; relate

Riboflavin (vitamin B2) is essential energy metabolism, but biomarkerstatus is rarely measured. The UK and Ireland are the only countries worldwide to have included a riboflavinbiomarker in national dietary surveys. Some concern exists in both countries regarding the large proportion ofadults showing low riboflavin status, measured using erythrocyte glutathione reductase activation coefficient(EGRac) (the gold-standard marker), but the functional significance of such findings is unclear since in general,with the exception of younger women, dietary intakes of British and Irish adults are within dietary referenceranges. Elsewhere in the world (including Canada and US), riboflavin biomarkers are not measured in nutritionsurveys because the existing biomarker EGRac requires very specific pre-analysis processing, unfeasible in mostsettings. DERIVE will develop accessible riboflavin biomarkers in plasma (FMN, FAD, riboflavin) and identifywhich most sensitively reflect dietary intakes and food sources of riboflavin in biobanked population basedcohorts from Ireland (n=1136) and Canada (n=1200), and are in best agreement with EGRac. The functionalsignificance of riboflavin will be evaluated using samples from previous placebo-controlled riboflavininterventions (n=537; UK cohorts) to test whether correcting low status is associated with a functional responserelated to a known metabolic role of riboflavin, the FMN-dependent generation of active vitamin B6 (i.e. PLP) intissues. Finally we will demonstrate an important health effect of riboflavin by investigating its role in modulatingblood pressure via a novel gene-nutrient interactive effect mediated through the FAD-dependent folatemetabolising enzyme methylenetetrahydrofolate reductase (MTHFR).

核黄素（维生素B2）是必需的能量代谢，但生物标志物状态很少测量。英国和爱尔兰是世界上仅有的两个将核黄素生物标志物纳入国家饮食调查的国家。在这两个国家中存在一些担忧，即大部分成年人显示低核黄素状态，使用红细胞谷胱甘肽还原酶活化系数（EGRac）（金标准标记物）测量，但这些发现的功能意义尚不清楚，因为一般来说，除了年轻女性，英国和爱尔兰成年人的饮食摄入量在饮食参考范围内。在世界其他地方（包括加拿大和美国），营养调查中没有测量核黄素生物标志物，因为现有的生物标志物EGRac需要非常具体的分析前处理，在大多数情况下是不可行的。DERIVE将开发血浆中可获得的核黄素生物标志物（FMN、FAD、核黄素），并在来自爱尔兰（n=1136）和加拿大（n=1200）的基于生物库的人群队列中识别最敏感地反映核黄素饮食摄入量和食物来源的生物标志物，并与EGRac最一致。核黄素的功能意义将使用来自先前安慰剂对照的核黄素干预的样本（n=537; UK队列）来评估，以测试纠正低状态是否与已知的核黄素代谢作用相关的功能反应相关，即组织中活性维生素B6（即PLP）的FMN依赖性产生。最后，我们将通过研究核黄素在调节血压中的作用来证明核黄素对健康的重要作用，这种作用是通过FAD依赖性叶酸代谢酶亚甲基四氢叶酸还原酶（MTHFR）介导的一种新的基因-营养相互作用来实现的。

项目成果

Helene McNulty Research Blog: 'Members Research Series' of the Royal Irish Academy

海伦·麦克纳尔蒂研究博客：爱尔兰皇家科学院“会员研究系列”

• 发表时间: 2021
• 作者: Helene McNulty

Riboflavin Status and Risk of Anaemia during Pregnancy: Findings from the OptiPREG Study

核黄素状态和怀孕期间贫血的风险：OptiPREG 研究的结果

• 发表时间: 2021
• 期刊: Journal of Human Nutrition and Dietetics
• 影响因子: 3.3
• 作者: Duffy B

Does riboflavin deficiency have a role to play in anaemia and hypertension in pregnancy?

核黄素缺乏是否会导致妊娠期贫血和高血压？

• 发表时间: 2021
• 期刊: Professional Nutrition & Dietetic Review
• 作者: B. Duffy

Guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals: Draft for internal testing.

• DOI: 10.2903/j.efsa.2022.e200102
• 发表时间: 2022-01
• 期刊: EFSA journal. European Food Safety Authority
• 作者: EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA);Turck D;Bohn T;Castenmiller J;De Henauw S;Hirsch-Ernst KI;Knutsen HK;Maciuk A;Mangelsdorf I;McArdle HJ;Peláez C;Pentieva K;Siani A;Thies F;Tsabouri S;Vinceti M;Aggett P;Crous Bou M;Cubadda F;de Sesmaisons Lecarré A;Martino L;Naska A
• 通讯作者: Naska A

Conversion of calcium-l-methylfolate and (6S)-5-methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents.

• DOI: 10.2903/j.efsa.2022.7452
• 发表时间: 2022-08
• 期刊: EFSA JOURNAL
• 影响因子: 3.3
• 作者: Turck, Dominique;Bohn, Torsten;Castenmiller, Jacqueline;De Henauw, Stefaan;Hirsch-Ernst, Karen Ildico;Knutsen, Helle Katrine;Maciuk, Alexandre;Mangelsdorf, Inge;McArdle, Harry J.;Naska, Androniki;Pelaez, Carmen;Siani, Alfonso;Thies, Frank;Tsabouri, Sophia;Vinceti, Marco;Cubadda, Francesco;Abrahantes, Jose Cortinas;Dumas, Celine;Ercolano, Valeria;Titz, Ariane;Pentieva, Kristina
• 通讯作者: Pentieva, Kristina