Guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals: Draft for internal testing.
Guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals: Draft for internal testing.
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DOI：
10.2903/j.efsa.2022.e200102
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Naska A
中科院分区：
文献类型：
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作者：
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA);Turck D;Bohn T;Castenmiller J;De Henauw S;Hirsch-Ernst KI;Knutsen HK;Maciuk A;Mangelsdorf I;McArdle HJ;Peláez C;Pentieva K;Siani A;Thies F;Tsabouri S;Vinceti M;Aggett P;Crous Bou M;Cubadda F;de Sesmaisons Lecarré A;Martino L;Naska A
维生素和必需矿物质是人体正常功能所必需的微量营养素。然而，如果过量食用，它们可能会对健康产生不利影响。可耐受摄入量上限（UL）的概念是一个基于科学的参考值，旨在支持政策制定者和其他相关参与者管理过量营养素摄入的风险。EFSA制定维生素和矿物质UL的原则最初是由食品科学委员会于2000年制定的。自那时以来，已经积累了经验，科学领域也得到了发展。EFSA营养、新型食品和食品过敏原小组的这份指南提供了一个更新的框架，以支持EFSA的UL评估。它涵盖了与风险评估规划（问题的提出和方法的定义）及其实施（证据检索、评估、综合、整合、不确定性分析）有关的各个方面。与前一个框架一样，适用为食品中化学品风险评估制定的一般原则（危害识别、危害特性描述、摄入量评估、风险特性描述）。营养素特有的是它们的生物化学和生理作用以及维持营养素的系统内稳态和身体负荷的特异性和选择性机制。在进行营养素风险评估时必须考虑这些因素。本文件是一份指南草案，将在为期一年的试点阶段应用于EFSA的评估，并在必要时进行修订和补充。在最终确定指导之前，将进行公众咨询。
Vitamins and essential minerals are micronutrients that are essential for the normal functioning of the human body. However, they may lead to adverse health effects if consumed in excess. The concept of a tolerable upper intake level (UL) is a science‐based reference value, which was introduced to support policy‐makers and other relevant actors in managing the risks of excess nutrient intake. EFSA’s principles for establishing ULs for vitamins and minerals were originally developed by the Scientific Committee on Food in 2000. Since then, experience has been gained and the scientific field developed. This guidance from the EFSA Panel on Nutrition, Novel Foods and Food Allergens provides an updated framework to support EFSA’s UL assessments. It covers aspects related to the planning of the risk assessment (problem formulation and definition of methods) and its implementation (evidence retrieval, appraisal, synthesis, integration, uncertainty analysis). As in the previous framework, the general principles developed for the risk assessment of chemicals in food are applied (hazard identification, hazard characterisation, intake assessment, risk characterisation). Peculiar to nutrients are their biochemical and physiological roles and the specific and selective mechanisms that maintain the systemic homoeostasis and body burden of the nutrient. These must be considered when conducting a risk assessment of nutrients. This document constitutes a draft guidance that will be applied in EFSA’s assessments during a 1‐year pilot phase and be revised and complemented as necessary. Before finalisation of the guidance, a public consultation will be launched.
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影响因子：
3.3
作者：
Benford, Diane;Halldorsson, Thorhallur;Hardy, Anthony
通讯作者：
Hardy, Anthony
影响因子：
3.3
作者：
Agostoni, Carlo;Bresson, Jean-Louis;Verhagen, Hans
通讯作者：
Verhagen, Hans
DOI：
10.2903/j.efsa.2021.6479
发表时间：
2021-03
期刊：
EFSA journal. European Food Safety Authority
影响因子：
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作者：
EFSA Scientific Committee;More S;Bampidis V;Benford D;Bragard C;Halldorsson T;Hougaard Bennekou S;Koutsoumanis K;Machera K;Naegeli H;Nielsen S;Schlatter J;Schrenk D;Silano V;Turck D;Younes M;Aggett P;Castenmiller J;Giarola A;de Sesmaisons-Lecarré A;Tarazona J;Verhagen H;Hernández-Jerez A
通讯作者：
Hernández-Jerez A
影响因子：
3.3
作者：
通讯作者：
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影响因子：
3.3
作者：
Hardy, Anthony;Benford, Diane;Schlatter, Josef R.
通讯作者：
Schlatter, Josef R.