GALLBLADDER DISEASE AGGREGATION AMONG MEXICAN-AMERICANS

墨西哥裔美国人胆囊疾病聚集

• 批准号: 3232940
• 负责人: WILLIAM J. SCHULL
• 金额: $ 41.01万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3232940
• 关键词: Mexican Americans; Native Americans; biliary tract disorder diagnosis; cholecystectomy; cholelithiasis; disease /disorder proneness /risk; epidemiology; gallbladder disorder; genetic markers; human population genetics; human subject; hypertension; interview; linkage mapping; longitudinal human study; obesity; sign /symptom; ultrasonography

At the population level, Mexican-Americans have rates of gallbladder disease, primarily cholelithiasis, which are at least two- to three-fold higher than comparable Caucasians or Blacks. Among Mexican-Americans in South Texas, and likely elsewhere, no other disease, save diabetes, dominates the health status as does gallbladder disease. In spite of the high rates and health impact, relatively little is known about the epidemiology of gallbladder disease in this group and even less about its familial aggregation. It is clear that the traditional conceptions are inadequate. The ethnic distribution of the disease closely parallels the degree of genetic admixture with Amerindians and we demonstrate that the risk in first degree relatives is twice that of random individuals or spouses implicating genetic sources of population and familial aggregation. The purpose of this research is to establish the prevalence of both symptomatic and asymptomatic gallbladder disease through the use of ultrasonography and to elucidate the risk factors of disease; including diabetes, body mass, lipids, serum bile acids and urinary steroids. Additionally, we will assess the degree to which the observed aggregation is due to genetic admixture with Amerindians and the genetic and environmental sources of familial aggregation. The design consists of a random sample of 1000 individuals residing in Starr County, Texas, from which 100 cases and 100 disease free controls will be selected. All screened individuals and first degree relatives of cases will have a comprehensive physical examination which will include ultrasound evaluation of the gallbladder and various laboratory and genetic marker determinations. In addition, the cases and controls will have serum bile acid and urinary steroid compositions determined. In addition to linkage and verification of relatedness, the genetic markers will be used to determine individual affinities to ancestral populations and these related to the distribution of disease. Approximately three years following initial examination, the controls will be re-examined to detect the development of symptomatic or "silent" gallbladder disease. This will allow evaluation of the sources of change in disease status. In summary, the research proposed will document at the population and family level the degree and sources of aggregation of gallbladder disease, its concomitants and association with other disease, most notably diabetes and obesity, and whether these diseases represent separate manifestations of a common cause or whether they are etiologically independent.

在人口水平上，墨西哥裔美国人的胆囊率 疾病，主要是胆石症，至少有两到三倍 比可比的高加索人或黑人高。在墨西哥裔美国人中 南得克萨斯州，可能在其他地方，除了糖尿病，没有其他疾病， 主宰健康状况的还有胆囊病。尽管有 高发病率和对健康的影响，相对知之甚少 本组人群中胆囊病的流行情况，对其流行病学的了解更少 家族聚集性。很明显，传统的观念是 不够充分。这种疾病的种族分布与 与美洲印第安人的基因混合程度，我们证明了 一级亲属的风险是随机个体的两倍或 配偶涉及人口和家庭的遗传来源 聚合。这项研究的目的是确定患病率。 有症状和无症状的胆囊病通过使用 超声波检查和阐明疾病的危险因素；包括 糖尿病、体重、血脂、血清胆汁酸和尿类固醇。 此外，我们将评估观察到的聚集的程度 是由于基因与美洲印第安人的混合以及基因和 家庭聚集性的环境来源。该设计由一个 居住在德克萨斯州斯塔尔县的1000人的随机样本，来自 将选出100例病例和100例无病对照。全 接受筛查的个人和病例的一级亲属将拥有 全面的体检，包括超声波检查 胆囊癌和各种实验室及遗传标志物 决定。此外，病例和对照组将会有血清胆汁。 尿酸和类固醇成分测定。除了链接之外 和亲缘关系的验证，这些遗传标记将被用于 确定个人与祖先群体的亲缘关系及其相关 疾病的传播。大约三年后 初步检查后，将重新检查控制措施，以检测 出现症状或“无症状”的胆囊病。这将是 允许评估疾病状况的变化来源。总而言之， 拟议的研究将在人口和家庭层面记录 胆囊病及其伴发疾病的聚集程度和来源 并与其他疾病有关，最明显的是糖尿病和肥胖症 这些疾病是否代表着共同原因的不同表现 或者它们是否在病因上是独立的。