FERRIC ION SEQUESTERING AGENTS: IRON REMOVAL IN MAN

一些聚儿茶酚螯合剂已被用来制备 2，3-二羟基苯甲酰(DHB)或其衍生物，其中苯甲酸 环在五个位置被-SO3-或在四个位置取代 By-CO2-。在每种情况下，将DHB基团附加到多胺主链上。至 Date、直链三胺(如亚精胺)、1，3，5-三氨基甲苯和 三脚胺三氨基乙胺都被用作分子骨架。 在接下来的一年，我们打算继续探索合成 三苯二酚螯合剂中DHB的4-羧基取代衍生物。 根据动物试验的结果，将尝试优化 通过主干结构的变化来确定这些络合物的几何构型。 我们还计划探索新的铁络合剂的分子结构， 并检查到目前为止制备的那些材料的热力学性质。

A number of polycatechol chelating agents have been prepared using the 2,3-dihydroxybenzoyl (DHB) group or derivatives of it in which the benzoic acid ring has been substituted at the five position by -SO3- or at the four position by -CO2-. In each case the DHB groups are appended to a polyamine backbone. To date, linear triamines (such as spermidine), 1,3,5,-triaminomethylbenzene, and the tripod amine triaminoethylamine have all been used as molecular skeletons. During the next year we intend to continue to explore the synthesis of 4-carboxyl-substituted derivatives of DHB in tricatechol chelating agents. Depending upon the results of animal tests, attempts will be made to optimize the geometries of these complexes through variation of the backbone structure. We also plan to explore new molecular architectures for ferric chelating agents, and examine the thermodynamic properties of those prepared to date.