A proposal for the purchase of a new Cu anode Microsource X-ray Diffractometer wi

关于购买新型铜阳极微源X射线衍射仪的提案

• 批准号: 7794643
• 负责人: KENNETH N RAYMOND
• 金额: $ 50万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2011-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794643
• 关键词: Anodes; California; Chemicals; Chemistry; Data; Disease; Drug Delivery Systems; Funding; Generations; Laboratories; Life; Research Personnel; Roentgen Rays; Structure; Techniques; Technology; United States National Institutes of Health; Universities; X-Ray Crystallography; college; improved; instrumentation; research study

DESCRIPTION (provided by applicant): The College of Chemistry X-ray Crystallography Facility at the University of California, Berkeley is requesting a total of $500,000 in funding from the National Institutes of Health for the purchase of a new single crystal X-ray diffractometer. The facility is oversubscribed as it is and current instrumentation in the laboratory is beginning to reach the end of its useful life and will need to be replaced shortly. In addition, new advances in technology allow newer instrumentation to be much more sensitive and versatile than first generation CCD diffractometers. Considering the amount of NIH-supported structures solved in this facility (over 250 per year), a new x-ray diffractometer for the facility will instantly improve the quality and range of data we are able to collect for NIH researchers. HEALTH RELEVANCE: The determination of the chemical and absolute structure of newly synthesized compounds is of utmost importance for potential drug targets used to treat diseases and illnesses. Single Crystal X-ray Crystallography is the one technique that can unambiguously give the chemical and absolute structure information necessary in one experiment.

描述（由申请人提供）：加州大学伯克利分校化学学院X射线晶体学设施正在向美国国立卫生研究院申请总额为50万美元的资金，用于购买一台新的单晶X射线衍射仪。该设施目前已超额使用，实验室现有的仪器已开始达到其使用寿命，不久将需要更换。此外，新技术的进步使新仪器比第一代CCD衍射仪更加灵敏和通用。考虑到该设施中解决的NIH支持结构的数量（每年超过250个），该设施的新X射线衍射仪将立即提高我们能够为NIH研究人员收集的数据的质量和范围。 健康相关性：新合成化合物的化学和绝对结构的确定对于用于治疗疾病的潜在药物靶点是极其重要的， 疾病。单晶X射线晶体学是一种可以在一个实验中明确给出必要的化学和绝对结构信息的技术。

项目成果

Synthetic efforts toward the Lycopodium alkaloids inspires a hydrogen iodide mediated method for the hydroamination and hydroetherification of olefins.

• DOI: 10.1002/chem.201406242
• 发表时间: 2015-03
• 期刊: Chemistry
• 作者: P. Leger;Rebecca A. Murphy;E. Pushkarskaya;Richmond Sarpong

Control of clustering behavior in anionic cerium(iii) corrole complexes: from oligomers to monomers.

• DOI: 10.1039/c6dt03884k
• 发表时间: 2016-11-22
• 期刊: Dalton transactions (Cambridge, England : 2003)
• 作者: Armstrong KC;Hohloch S;Lohrey TD;Zarkesh RA;Arnold J;Anstey MR
• 通讯作者: Anstey MR

Enantioselective α-Amination Enabled by a BINAM-Derived Phase-Transfer Catalyst.

• DOI: 10.1039/c4sc02494j
• 发表时间: 2015-01-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Nelson HM;Patel JS;Shunatona HP;Toste FD
• 通讯作者: Toste FD

Reductive Elimination from Phosphine-Ligated Alkylpalladium(II) Amido Complexes To Form sp3 Carbon-Nitrogen Bonds.

膦连接的烷基钯 (II) 氨基配合物的还原消除形成 sp3 碳-氮键。

• DOI: 10.1021/jacs.8b00928
• 发表时间: 2018
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Peacock,DMatthew;Jiang,Quan;Hanley,PatrickS;Cundari,ThomasR;Hartwig,JohnF
• 通讯作者: Hartwig,JohnF

Annulative Methods Enable a Total Synthesis of the Complex Meroterpene Berkeleyone A

• DOI: 10.1021/jacs.6b10397
• 发表时间: 2016-11-16
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Ting, Chi P.;Xu, Gong;Maimone, Thomas J.
• 通讯作者: Maimone, Thomas J.