A proposal for the purchase of a new Cu anode Microsource X-ray Diffractometer wi

描述(由申请人提供)：加州大学伯克利分校的化学学院X射线晶体设施要求美国国立卫生研究院提供总计500,000美元的资金，用于购买新的单晶X射线衍射仪。该设施目前已被超额认购，目前实验室中的仪器设备已开始达到其使用寿命的尽头，不久将需要更换。此外，新技术的进步使较新的仪器比第一代CCD衍射仪具有更高的灵敏度和更多的用途。考虑到在该设施中解决的NIH支持的结构的数量(每年超过250个)，该设施的新的X射线衍射仪将立即提高我们能够为NIH研究人员收集的数据的质量和范围。 与健康相关：确定新合成化合物的化学结构和绝对结构对于用于治疗疾病和 疾病。单晶X射线结晶学是一种可以在一次实验中毫不含糊地给出所需的化学和绝对结构信息的技术。

DESCRIPTION (provided by applicant): The College of Chemistry X-ray Crystallography Facility at the University of California, Berkeley is requesting a total of $500,000 in funding from the National Institutes of Health for the purchase of a new single crystal X-ray diffractometer. The facility is oversubscribed as it is and current instrumentation in the laboratory is beginning to reach the end of its useful life and will need to be replaced shortly. In addition, new advances in technology allow newer instrumentation to be much more sensitive and versatile than first generation CCD diffractometers. Considering the amount of NIH-supported structures solved in this facility (over 250 per year), a new x-ray diffractometer for the facility will instantly improve the quality and range of data we are able to collect for NIH researchers. HEALTH RELEVANCE: The determination of the chemical and absolute structure of newly synthesized compounds is of utmost importance for potential drug targets used to treat diseases and illnesses. Single Crystal X-ray Crystallography is the one technique that can unambiguously give the chemical and absolute structure information necessary in one experiment.