UCL Biosciences Big Data

伦敦大学学院生物科学大数据

• 批准号: BB/R01356X/1
• 负责人: Richard Mott
• 金额: $ 71.78万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR01356X%2F1
• 关键词: UCL; Biosciences; Big; Data

Much research in the biosciences is transitioning away from experimental work towards computational analysis. This involves a massive increase in the volume of data to be analysed and in the computational power to analyse it, and in the speed and capacity of computer networks to move data from the collection instruments to the compute clusters used to analyse it and then onto data archives. University College London is one of the leading research-focused univsesities in the world. The UCL division of Biosciences undertakes an increasing amoutn of research involving Big Data. This includes large-scale biological and cellular imaging and DNA sequencing, much of it funded by the BBSRC and other UK research organisations.The proposal aims to put in place a new computational infractructure within UCL Biosciences that links its data generation groups together with augemted compute and archive facilities. This involves installing a high-speed network capable of transferring up to 10 Gb/s from data collection instruments to the computer clusters and data archives managed in the UCL Depts of Computer Science and Research Computing. It also involves purchasing over 700 computers for data analysis and over two petabytes of disk storage, in a combination of high-speed disk attach to thte compute cluster and lower speed cheaper disk for archiving. This combination of network, compute and storage will position UCL Biosciences to grow as a UK centre of research excellence over the next 4 years.

生物科学中的许多研究正在从实验工作转向计算分析。这涉及到需要分析的数据量和分析数据的计算能力的大幅度增加，以及计算机网络将数据从收集仪器转移到用于分析数据的计算机集群，然后转移到数据档案的速度和能力的大幅度增加。伦敦大学学院是世界领先的研究型大学之一。伦敦大学学院生物科学部承担了越来越多的涉及大数据的研究。这包括大规模的生物和细胞成像和DNA测序，其中大部分由BBSRC和其他英国研究机构资助。该提案旨在在UCL Biosciences内建立一个新的计算基础架构，将其数据生成组与增强的计算和存档设施联系在一起。这涉及到安装一个高速网络，能够将数据收集仪器传输到UCL计算机科学和研究计算部门管理的计算机集群和数据档案，传输速度高达10 Gb/s。它还涉及购买700多台计算机进行数据分析和超过两个PB的磁盘存储，在高速磁盘连接到计算集群和低速更便宜的磁盘存档的组合。这种网络，计算和存储的结合将使UCL Biosciences在未来4年内成长为英国卓越的研究中心。

项目成果

Additional file 2 of Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China

中国耐甲氧西林金黄色葡萄球菌（MRSA）谱系更替的驱动因素补充文件2

• DOI: 10.6084/m9.figshare.16901002
• 发表时间: 2021
• 作者: Chen H

Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China.

• DOI: 10.1186/s13073-021-00992-x
• 发表时间: 2021-10-28
• 期刊: Genome medicine
• 影响因子: 12.3
• 作者: Chen H;Yin Y;van Dorp L;Shaw LP;Gao H;Acman M;Yuan J;Chen F;Sun S;Wang X;Li S;Zhang Y;Farrer RA;Wang H;Balloux F
• 通讯作者: Balloux F

Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.

• DOI: 10.1186/s13059-023-03060-2
• 发表时间: 2023-09-29
• 期刊: Genome biology
• 影响因子: 12.3

Additional file 1 of Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing

优势的附加文件1在哺乳动物中很常见，与反式作用基因表达和选择性剪接有关

• DOI: 10.6084/m9.figshare.24597605
• 发表时间: 2023
• 作者: Cui L

Additional file 15 of Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing

优势的附加文件 15 在哺乳动物中很常见，与反式作用基因表达和选择性剪接有关

• DOI: 10.6084/m9.figshare.24597650
• 发表时间: 2023
• 作者: Cui L