EPIDEMIOLOGY OF LEAD, DIET AND BLOOD PRESSURE

铅、饮食和血压的流行病学

• 批准号: 3253536
• 负责人: Howard Hu
• 金额: $ 39.85万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3253536
• 关键词: blood pressure; clinical biomedical equipment; clinical chemistry; diagnosis quality /standard; diet; dietary calcium; dopamine; environmental contamination; epidemiology; fluorescence; hematology; human subject; hypertension; lead poisoning; longitudinal human study; male; urinalysis

The main objective of this research is to elucidate the inter-relationships between accumulated lead burden measured by K-X-Ray Fluorescence (K-XRF), blood lead levels, dietary calcium, and blood pressure. Previous studies have shown a positive cross-sectional association between blood lead at low levels experienced by the general population and blood pressure and a negative association between dietary calcium and blood pressure. There have been no studies that have assessed the possibility that accumulated lead burden is more closely associated than blood lead with blood pressure increases, and that lead may confound the relationship between dietary calcium and blood pressure; and no studies on the longitudinal relationship between blood lead levels and blood pressure at multiple points in time. The specific aims are focused on examining the above relationships in the Normative Aging Study (NAS), a group of men who have been followed longitudinally since 1962 and are expected to have accumulated lead burdens from low-level environmental exposures that are similar to those sustained by the general population. In preliminary studies we discuss data on blood lead levels, dietary calcium, and blood pressure in the NAS; a study validating the use of frozen red cells for lead analysis in the NAS; our state-of-the art K-XRF instrument and its precision, accuracy, and calibration; two population studies of K-XRF; and a study of the distribution of lead in cadaveric skeletons. In the research plan we propose to use our K-XRF instrument to measure lead burden in NAS subjects, thaw and analyze frozen red cell samples that are available on each NAS subject from multiple visits since the 1960s, and continue collection of fresh blood leads. This would add to the data already being collected, including dietary information using a semi-quantitative food frequency questionnaire, 24 hour urinary amines, blood pressures, and many other physical exam and laboratory parameters. Finally, we outline our strategy for analysis of the data including specific approaches for the blood lead-blood pressure data at multiple points in time.

本研究的主要目的是阐明它们之间的相互关系 在K-X-射线荧光(K-XRF)测量的累积铅负荷之间， 血铅水平、膳食钙和血压。以前的研究 在低水平的血铅水平之间显示出正的横截面关联 一般人群所经历的水平和血压以及 饮食中的钙与血压呈负相关。有 一直没有研究评估累积的铅 负担比血铅与血压的关系更密切 增加，而铅可能会扰乱饮食之间的关系 钙与血压的关系；没有关于这种纵向关系的研究 多个时间点的血铅水平和血压之间的关系。 具体目标集中在审查上述关系在 标准老龄化研究(NAS)，一组被跟踪的男性 自1962年以来一直是纵向的，预计将积累铅负担 来自低水平的环境暴露，类似于持续的 被普通民众所接受。 在初步研究中，我们讨论了血铅水平、饮食 NAS中的钙和血压；一项验证使用 用于NAS铅分析的冰冻红细胞；我们最先进的K-XRF 仪器及其精密度、准确度和校准；两个总体 K-XRF研究和铅在身体中分布的研究 骷髅。 在研究计划中，我们建议使用我们的K-XRF仪器来测量铅 NAS受试者的负担，解冻和分析冰冻的红细胞样本 自20世纪60年代以来，每个NAS对象都可以通过多次访问获得 继续收集新的血铅。这将增加数据 已经被收集，包括使用 半定量食物频率问卷，24小时尿胺， 血压，以及许多其他体检和实验室参数。 最后，我们概述了我们的数据分析策略，包括 多点血铅-血压数据的具体处理方法 时间点。