CHILDHOOD BLOOD LEAD--AIR, SOIL, AND DUST SOURCES

儿童血铅——空气、土壤和灰尘来源

• 批准号: 3252883
• 负责人: CAROL R ANGLE
• 金额: $ 31.66万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3252883
• 关键词: air pollution; blood chemistry; dust; environmental toxicology; food contamination; human tissue; isotope dilution method; lead poisoning; longitudinal human study; mass spectrometry; preschool child (1-5); soil pollution; urinalysis

DESCRIPTION: (Adapted from the investigator's specific aims) This is a pilot, longitudinal study, employing thermal ionization/mass spectrometry (TI/MS) isotopic dilution analysis in an ultraclean laboratory, of environmental sources of childhood blood lead. The study will be conducted on 24 children 18-36 months old who live in the urban residential area of a smelter city where the air lead is now negligible, but no soil lead remediation programs have been undertaken. It tests the hypothesis that food lead, non-food lead and endogenously mobilized lead can be quantified as the primary sources of childhood blood lead. In this study "food" or PbF means the 24 hour intake of all food and water after household preparation but before it is handled by the child. The isotopic ratios of lead in the adult diet are remarkably constant. If this is true in children, then random variances in the isotopic ratios of blood lead (PbB-IR) reflect individual differences in non-food sources. In this study hand dust lead (PbH) serves as the surrogate for composite non-food sources in the environment. It is proposed that cyclic changes in the concentrations or isotopic ratios of blood lead, independent of the contributions of food, air and hand dust lead, represent mobilization of endogenous sources of blood lead.

描述：（根据研究者的具体目的改编）这是一个