CHILDHOOD BLOOD LEAD--AIR, SOIL, AND DUST SOURCES

儿童血铅——空气、土壤和灰尘来源

• 批准号: 3252880
• 负责人: CAROL R ANGLE
• 金额: $ 25.57万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3252880
• 关键词: air pollution; blood chemistry; dust; environmental toxicology; food contamination; human tissue; isotope dilution method; lead poisoning; longitudinal human study; mass spectrometry; preschool child (1-5); soil pollution; urinalysis

DESCRIPTION: (Adapted from the investigator's specific aims) This is a pilot, longitudinal study, employing thermal ionization/mass spectrometry (TI/MS) isotopic dilution analysis in an ultraclean laboratory, of environmental sources of childhood blood lead. The study will be conducted on 24 children 18-36 months old who live in the urban residential area of a smelter city where the air lead is now negligible, but no soil lead remediation programs have been undertaken. It tests the hypothesis that food lead, non-food lead and endogenously mobilized lead can be quantified as the primary sources of childhood blood lead. In this study "food" or PbF means the 24 hour intake of all food and water after household preparation but before it is handled by the child. The isotopic ratios of lead in the adult diet are remarkably constant. If this is true in children, then random variances in the isotopic ratios of blood lead (PbB-IR) reflect individual differences in non-food sources. In this study hand dust lead (PbH) serves as the surrogate for composite non-food sources in the environment. It is proposed that cyclic changes in the concentrations or isotopic ratios of blood lead, independent of the contributions of food, air and hand dust lead, represent mobilization of endogenous sources of blood lead.

描述：（改编自研究者的具体目标）这是一个 试点，纵向研究，采用热电离/质谱法 (TI/MS）同位素稀释分析， 儿童血铅的环境来源。 本研究的开展将 对24名18-36个月的儿童谁住在城市居民区的a 冶炼城市的空气铅现在可以忽略不计，但没有土壤铅 已实施补救方案。 它验证了一个假设， 食物中的铅、非食物中的铅和内源性铅都可以量化 是儿童血铅的主要来源。 在这项研究中，“食物”或 PbF指的是家庭生活后24小时内所有食物和水的摄入量 但在孩子做好准备之前。 同位素比值 成人饮食中的铅含量非常稳定 如果这是真的， 儿童，然后随机变化的同位素比率的血铅 （PbB-IR）反映了非食物来源的个体差异。 本研究 手尘铅（PbH）作为复合非食物来源的替代品 环境中。 有人提出，周期性的变化， 血铅浓度或同位素比值，独立于 贡献的食物，空气和手尘铅，代表动员 内源性血铅。