FAMILIAL EPIDEMIOLOGY--IDDM ARTHRITIS & THYROID DISEASE
FAMILIAL EPIDEMIOLOGY--IDDM ARTHRITIS & THYROID DISEASE
批准号:
3246123
负责人:
JANICE S DORMAN
金额:
$36.5万
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-09-30 至 1996-09-29
关键词:
alleles antiviral antibody autoimmune thyroiditis diabetes mellitus genetics disease /disorder proneness /risk endocrine disorder diagnosis epidemiology family genetics gene expression genetic polymorphism histocompatibility typing human ecology human genetic material tag human morbidity human subject insulin dependent diabetes mellitus longitudinal human study major histocompatibility complex metabolism disorder diagnosis musculoskeletal disorder diagnosis polymerase chain reaction questionnaires rheumatoid arthritis western blottings
中文摘要
已知6号染色体的HLA区域中的基因赋予
胰岛素依赖型糖尿病(IDDM)和其他
自身免疫性疾病,例如类风湿性关节炎(RA)和自身免疫性疾病,
甲状腺疾病(ATD)。 HLA-DR、DQ和DP位点特异性多态性
与这些疾病有关 然而,
在个体内发生一种以上自身免疫性疾病,或
他们在家庭中的聚集情况仍不清楚。 可能的解释
包括HLA易感基因间连锁不平衡和/或
共同的环境因素,可能与他们各自的
病因学 这些疾病在女性中的发病率增加
这表明荷尔蒙因素也可能参与其中。 探讨
关于IDDM RA和ATD之间的相互关系,我们将讨论两个具体问题,
目标。
目的1:估计RA和ATD在以下人群中的累积发病率:a)IDDM
病例,B)他们的父母和兄弟姐妹,以及c)一般人群
宾夕法尼亚州阿勒格尼县 我们假设,发病率将是最高的
在胰岛素依赖型糖尿病病例中,在一般人群中最低。
目的2:对遗传性/
环境的相互作用和ATD、RA和IDDM的聚集,
家庭a)我们假设在家庭中,患有IDDM的个体,
ATD和RA将共享HLA单倍型。 家庭之间的比较将
可能揭示了每种疾病的独特的II类易感性等位基因。
B)我们假设,在控制了易感性之后,
与IDDM,RA或ATD将有不同的病毒抗体谱和/或
暴露于其他环境危险因素,而不是家庭成员,
这些疾病。 然而,共同的环境因素可能有助于
在个体内发生一种以上的自身免疫性疾病,
亲戚之间。
新兴的分子流行病学领域已经显著地
有助于我们了解基因与环境的相互作用
在家庭和人群中的胰岛素依赖型糖尿病。 通过扩大我们
研究模型,并采用最先进的方法进行遗传
在家庭流行病学分析中,我们将确定候选HLA
易感基因和环境风险因素,有助于
IDDM、RA和ATD在个体中发生及其聚集性
在家庭中。 确定潜在的病因决定因素可能导致
预防这些自身免疫性疾病,这是最终的
流行病学研究的目的。
英文摘要
Genes in the HLA region of chromosome 6 are known to confer
susceptibility to insulin dependent diabetes mellitus (IDDM) and other
autoimmune disorders, such as rheumatoid arthritis (RA) and autoimmune
thyroid disease (ATD). Specific HLA-DR, DQ and DP locus polymorphisms
have been associated with these conditions. However, the causes of the
occurrence of more than one autoimmune disease within an individual, or
their clustering in families remains unclear. Possible explanations
include linkage disequilibrium among HLA susceptibility genes and/or
common environmental factors that may be related to their respective
etiologies. The increased prevalence of these disorders among women
suggest that hormonal factors may also be involved. To investigate the
interrelationships between IDDM RA and ATD, we will address two Specific
Aims.
Aim 1: To estimate the cumulative incidence of RA and ATD in: a) IDDM
cases, b) their parents and siblings, and c) the general population of
Allegheny County, PA. We hypothesize that the incidence will be highest
among the IDDM cases, and lowest in the general, population.
Aim 2: To conduct an analytic epidemiologic investigation of genetic/
environmental interactions and the clustering of ATD, RA and IDDM in
families. a) We hypothesize that within families, individuals with IDDM,
ATD and RA will share HLA haplotypes. Comparison between families will
likely reveal unique class II susceptibility alleles for each disorder.
b) We hypothesize that after controlling for susceptibility, relatives
with IDDM, RA or ATD will have different viral antibody profiles and/or
exposure to other environmental risk factors than family members without
these diseases. However, common environmental factors may contribute to
the occurrence of more than one autoimmune disease within individuals and
among relatives.
The emerging field of molecular epidemiology has significantly
contributed to our knowledge of the genetic/environmental interactions
for IDDM within families and across populations. By expanding our
research models, and employing state-of-the-art approaches for genetic
epidemiologic analyses in families, we will identify candidate HLA
susceptibility genes and environmental risk factors that contribute to
the occurrence of IDDM, RA and ATD in an individual and their clustering
in families. Identification of potential etiologic determinants can lead
to the prevention of these autoimmune disorders, which is the ultimate
objective of epidemiologic research.
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专著(0)
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会议论文
Targeted Research and Academic Training of Nurses in Genomics
-
批准号:7652449
-
项目类别:
-
资助金额:$1.57万
-
财政年份:2006
-
负责人:JANICE S DORMAN
-
依托单位:
Targeted Research and Academic Training of Nurses in Genomics
-
批准号:7883361
-
项目类别:
-
资助金额:$8.81万
-
财政年份:2006
-
负责人:JANICE S DORMAN
-
依托单位:
Targeted Research and Academic Training of Nurses in Genomics
-
批准号:7066201
-
项目类别:
-
资助金额:$8.93万
-
财政年份:2006
-
负责人:JANICE S DORMAN
-
依托单位:
Targeted Research and Academic Training of Nurses in Genomics
-
批准号:7234838
-
项目类别:
-
资助金额:$29.59万
-
财政年份:2006
-
负责人:JANICE S DORMAN
-
依托单位:
Targeted Research and Academic Training of Nurses in Genomics
-
批准号:7414480
-
项目类别:
-
资助金额:$22.13万
-
财政年份:2006
-
负责人:JANICE S DORMAN
-
依托单位:
Asia-Pacific Diabetes Epidemiology Training Course
-
批准号:6367770
-
项目类别:
-
资助金额:$1.8万
-
财政年份:2001
-
负责人:JANICE S DORMAN
-
依托单位:
ASIA PACIFIC DIABETES EPIDEMIOLOGY TRAINING COURSE
-
批准号:2677430
-
项目类别:
-
资助金额:$2.0万
-
财政年份:1998
-
负责人:JANICE S DORMAN
-
依托单位:
MOLECULAR EPIDEMIOLOGY OF IDDM
-
批准号:2150405
-
项目类别:
-
资助金额:$25.22万
-
财政年份:1995
-
负责人:JANICE S DORMAN
-
依托单位:
MOLECULAR EPIDEMIOLOGY OF IDDM
-
批准号:2414890
-
项目类别:
-
资助金额:$24.08万
-
财政年份:1995
-
负责人:JANICE S DORMAN
-
依托单位:
MOLECULAR EPIDEMIOLOGY OF IDDM
-
批准号:2701165
-
项目类别:
-
资助金额:$13.73万
-
财政年份:1995
-
负责人:JANICE S DORMAN
-
依托单位:
MOLECULAR EPIDEMIOLOGY OF IDDM
-
批准号:2150406
-
项目类别:
-
资助金额:$23.64万
-
财政年份:1995
-
负责人:JANICE S DORMAN
-
依托单位:
MENOPAUSE, IDDM, AND AUTOIMMUNITY--THE FAD STUDY
-
批准号:6176483
-
项目类别:
-
资助金额:$53.32万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
FAMILIAL EPIDEMIOLOGY--IDDM ARTHRITIS & THYROID DISEASE
-
批准号:3246124
-
项目类别:
-
资助金额:$36.64万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
MENOPAUSE, IDDM, AND AUTOIMMUNITY--THE FAD STUDY
-
批准号:2859202
-
项目类别:
-
资助金额:$48.64万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
FAMILIAL EPIDEMIOLOGY--IDDM, ARTHRITIS & THYROID DISEASE
-
批准号:2143903
-
项目类别:
-
资助金额:$32.56万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
STANDARDS FOR GENETIC EPIDEMIOLOGIC STUDIES OF IDDM
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批准号:3434725
-
项目类别:
-
资助金额:$0.2万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
MENOPAUSE, IDDM, AND AUTOIMMUNITY--THE FAD STUDY
-
批准号:6380709
-
项目类别:
-
资助金额:$49.38万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
MENOPAUSE, IDDM, AND AUTOIMMUNITY--THE FAD STUDY
-
批准号:6634989
-
项目类别:
-
资助金额:$41.66万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
MENOPAUSE, IDDM, AND AUTOIMMUNITY--THE FAD STUDY
-
批准号:6517232
-
项目类别:
-
资助金额:$46.05万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
FAMILIAL EPIDEMIOLOGY--IDDM, ARTHRITIS & THYROID DISEASE
-
批准号:2143904
-
项目类别:
-
资助金额:$15.97万
-
财政年份:1992
-
负责人:JANICE S DORMAN
-
依托单位:
海外基金