ROLE OF IRON IN TOXICITIES AND PATHOLOGIES
ROLE OF IRON IN TOXICITIES AND PATHOLOGIES
批准号:
3253294
负责人:
STEVEN D. AUST
金额:
$8.75万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-05-01 至 1992-04-30
中文摘要
我们提出铁可以催化自由基氧化
英文摘要
We propose that iron catalyzes the free radical oxidation of
biomolecules that results in the toxicity of redox cycling
chemicals, irradiation damage and iron overload. The iron that
catalyzes these toxicities or pathologies must be a low molecular
weight chelate of iron which normally exists in very low
concentration or otherwise does not catalyze the oxidation of
tissue macromolecules. Upon iron overload or the exposure to
chemicals or conditions which promote the release of iron from
ferritin, the released iron has the potential to be toxic. We
hypothesize that this toxicity may be at least minimized by
ceruloplasmin catalyzed oxidation and sequestration of the iron in
ferritin. The long-term objective of the proposed research is to
study ferritin and ceruloplasmin with regards to their ability to
sequester iron in order to devise an effective therapeutic system.
We propose to determine if a number of redox cycling chemicals or
irradiation cause the release of iron from ferritin in vivo in a
number of tissues, and to determine if ceruloplasmin and ferritin
might provide protection against the toxicity of this iron. We
propose to study paraquat, diquat, carbon tetrachloride,
adriamycin, alloxan and Y-irradiation in their respective target
tissues. We propose to study the interactions between
ceruloplasmin and serum ferritin, three isoferritins, and the
recently described lipid-associated ferritin.
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会议论文
IRON LOADING INTO FERRITIN
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批准号:2906053
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项目类别:
-
资助金额:$16.73万
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财政年份:1997
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负责人:STEVEN D. AUST
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依托单位:
IRON LOADING INTO FERRITIN
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批准号:2749626
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项目类别:
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资助金额:$16.24万
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财政年份:1997
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负责人:STEVEN D. AUST
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依托单位:
IRON LOADING INTO FERRITIN
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批准号:2372437
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项目类别:
-
资助金额:$15.77万
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财政年份:1997
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负责人:STEVEN D. AUST
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依托单位:
IRON AND TOXICITES AND PATHOLOGIES
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批准号:2153931
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项目类别:
-
资助金额:$17.36万
-
财政年份:1989
-
负责人:STEVEN D. AUST
-
依托单位:
ROLE OF IRON IN TOXICITIES AND PATHOLOGIES
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批准号:3253295
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项目类别:
-
资助金额:$9.27万
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财政年份:1989
-
负责人:STEVEN D. AUST
-
依托单位:
ROLE OF IRON IN TOXICITIES AND PATHOLOGIES
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批准号:3253296
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项目类别:
-
资助金额:$12.47万
-
财政年份:1989
-
负责人:STEVEN D. AUST
-
依托单位:
ROLE OF IRON IN TOXICITIES AND PATHOLOGIES
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批准号:3253292
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项目类别:
-
资助金额:$10.13万
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财政年份:1989
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负责人:STEVEN D. AUST
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依托单位:
1989 GRC OXYGEN RADICALS IN BIOLOGY
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批准号:3434032
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项目类别:
-
资助金额:$1.25万
-
财政年份:1989
-
负责人:STEVEN D. AUST
-
依托单位:
ROLE OF IRON IN TOXICITIES AND PATHOLOGIES
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批准号:3253293
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项目类别:
-
资助金额:$12.12万
-
财政年份:1989
-
负责人:STEVEN D. AUST
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依托单位:
IRON AND TOXICITES AND PATHOLOGIES
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批准号:2518628
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项目类别:
-
资助金额:$18.85万
-
财政年份:1989
-
负责人:STEVEN D. AUST
-
依托单位:
IRON AND TOXICITES AND PATHOLOGIES
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批准号:2153932
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项目类别:
-
资助金额:$18.09万
-
财政年份:1989
-
负责人:STEVEN D. AUST
-
依托单位:
IRON AND TOXICITIES AND PATHOLOGIES
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批准号:2153930
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项目类别:
-
资助金额:$12.96万
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财政年份:1989
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负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:3104507
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项目类别:
-
资助金额:$1.0万
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财政年份:1988
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负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:3104511
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项目类别:
-
资助金额:$57.16万
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财政年份:1988
-
负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:3104509
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项目类别:
-
资助金额:$57.37万
-
财政年份:1988
-
负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:3104506
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项目类别:
-
资助金额:$4.5万
-
财政年份:1988
-
负责人:STEVEN D. AUST
-
依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:3104505
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项目类别:
-
资助金额:$54.07万
-
财政年份:1988
-
负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:3104504
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项目类别:
-
资助金额:$57.36万
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财政年份:1988
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负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:2153844
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项目类别:
-
资助金额:$62.9万
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财政年份:1988
-
负责人:STEVEN D. AUST
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依托单位:
BIOLOGICAL HAZARDOUS WASTE MANAGEMENT
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批准号:2153845
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项目类别:
-
资助金额:$26.0万
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财政年份:1988
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负责人:STEVEN D. AUST
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依托单位:
海外基金