Unlocking high-throughput analysis within the RNA epigenetics domain

解锁 RNA 表观遗传学领域的高通量分析

• 批准号: BB/S004947/1
• 负责人: Anastasia Callaghan
• 金额: $ 25.75万
• 依托单位: University of Portsmouth
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS004947%2F1
• 关键词: Unlocking; throughput; analysis; within; RNA

In the rapidly emerging field of RNA epigenetics, reversible chemical modifications of RNA by writer, reader and eraser proteins are known to play key roles in changing RNA activity and regulating critical cellular processes. Mass spectrometry and sequencing techniques are used to detect RNA modifications, but neither are capable of high-throughput analysis. To support the exponential growth of research in this field there is an urgent need for high-throughput approaches. Working with RNA epigenetics experts, Storm Therapeutics, this goal can be achieved by repurposing our patented RNA array platform technology to facilitate simultaneous analysis of multiple target RNAs for RNA modification detection. With market exclusivity, the tailoring of our RNA array into the RNA epigenetics domain offers a very significant increase in its utility, greatly increasing its market potential and substantially enhancing its attractiveness to potential licensees.

在迅速兴起的 RNA 表观遗传学领域，已知写入蛋白、读取蛋白和擦除蛋白对 RNA 的可逆化学修饰在改变 RNA 活性和调节关键细胞过程中发挥着关键作用。质谱和测序技术用于检测 RNA 修饰，但都无法进行高通量分析。为了支持该领域研究的指数级增长，迫切需要高通量方法。与 RNA 表观遗传学专家 Storm Therapeutics 合作，通过重新利用我们的专利 RNA 阵列平台技术，促进同时分析多个目标 RNA 以进行 RNA 修饰检测，可以实现这一目标。凭借市场独占性，将我们的 RNA 阵列定制到 RNA 表观遗传学领域可显着提高其效用，大大增加其市场潜力，并大幅增强其对潜在被许可人的吸引力。