VISUAL SYSTEM ORGANIZATION & DEVELOPMENT

研究的总体目标是了解功能 起源于视网膜的平行通路对 皮质视觉区 该提案是 研究在三个确定的渠道并行处理， 原猴纲灵长类动物的视觉系统，叫加拉哥。 的四项具体 这里概述的目标将调查转型的细节 外侧膝状体核（LGN）的视觉信息， 纹状皮质 在目标一中，建议进行研究， W样细胞通路在LGN中的作用（这是很好的 在Galagos开发）。 将进行聚类分析， 基于感受野确定LGN W样细胞的亚型 特性. 类W感受野特性的变化将是 在激活或失活丘后检查 神经元，以确定这一途径的作用。 在Aim II中，我们 建议研究W样细胞通路在纹状体中的作用， 皮层 细胞色素细胞中细胞的感受野特性 将检查层III中的氧化酶“斑点”，以确定这些斑点是否 细胞反映了其LGN W样细胞的生理特征 输入. 皮质“团块”细胞特性的变化将 阿索可在LGN层灭活后进行检查。 在Aim中 第三，纹状皮质层IV α和IV β中的细胞将被 检查以确定是否可以 建立反映他们的小细胞（X-lik）， 大细胞（Y样）LGN输入。 解剖连接 还将分析皮质层IV α和IV β。 最后， 在目的IV中，视网膜外和膝状体内的调制， 并行通道在LGN将研究通过分析 非视网膜输入的分布和来源以及 胆碱能传递

The overall aim of the research is to understand the functional contribution of parallel pathways originating in the retina to cortical visual areas. The proposal represents a continuation of studies on parallel processing in three identified channels in the visual system of the prosimian primate, galago. The four specific aims outlined here will investigate details of the transformation of visual information in the lateral geniculate nucleus (LGN) and striate cortex. In Aim I, studies are proposed that will examine the role of the W-like cell pathway in the LGN (which is well developed in galagos). Cluster analyses will be performed to determine subtypes of LGN W-like cells based on receptive field properties. Changes in W-like receptive field properties will be examined following activation or inactivation of collicular neurons to determine the role of this pathway. In Aim II, we propose studies on the role of the W-like cell pathway in striate cortex. Receptive field properties of cells in the cytochrome oxidase "blobs" in layer III will be examined to determine if these cells reflect a physiological signature of their LGN W-like cell input. Changes in the properties of the cortical "blob" cells will aso be examined following inactivation of the LGN layers. In Aim III, cells in striate cortical layers IV alpha and IV beta will be examined to determine if a physiological signature can be established that reflects their parvocellular (X-lik) and magnocellular (Y-like) LGN inputs. Anatomical connections of cortical layers IV alpha and IV beta will also be analyzed. Finally, in Aim IV, the extraretinal and intrageniculate modulation of parallel channels in the LGN will be studed by analyzing the distribution and source of non-retinal inputs and details of cholinergic transmission.