VISUAL SYSTEM ORGANIZATION AND DEVELOPMENT

描述：在PI的视觉信息处理工作模型中， 三个分离的平行途径（大细胞（M），小细胞（P）， 和koniocellular（K））从外侧膝状体核（LGN）到初级 视皮层（V1）由层状和房室（即， 细胞色素氧化酶（CO）斑点和斑点间）电路来合成 新的输出路径适合于下一个分析步骤。 在这 方案中，V1的单独输出层和隔室具有不同的模式 用于整合来自所有三个输入路径的信号并生成输出 支持纹外区的信号，专门化而不是特定的 属性，但用于更复杂的可视化分析。 根据这一模式，该项目的主要目标是测试 这些途径的重要性，定义输入途径如何参与 V1层和隔室的电路，并辨别所使用的策略 通过输出路径支持V1目标区域。 该提案的重点是 K和M输入路径以及到视觉区域2（V2）的输出路径， 背内侧视区（DM）和颞中视区 （MT）。 具体的目标是为了测试我们的假设产生的。 工作模式 在目标I中，PI将检查K途径以及该途径和其他途径如何 被集成在V1的CO-blob中。 在Aim II中，她将确定 LGN K（或M）细胞活性与眼球运动或行为的关系 本案无关 在目标III中，她将定义V1输出的组织 来自CO-blob柱的路径。 这项拟议研究的结果将 提供重要的新信息，从根本上了解如何 大脑处理视觉信息和一般的大脑结构。

DESCRIPTION: In the PI's working model of visual information processing, three segregated parallel pathways (magnocellular (M), parvicellular (P), and koniocellular (K)) from the lateral geniculate nucleus (LGN) to primary visual cortex (V1) are utilized by the laminar and compartmental (i.e. cytochrome oxidase (CO) blob and interblob) circuitry of V1 to synthesize new output pathways appropriate for the next steps of analysis. Within this scheme, separate output layers and compartments of V1 have distinct modes for integrating signals from all three input pathways and generating output signals that support extrastriate areas, specialized not for specific attributes, but for more complex visual analysis. In light of this model, the project's broad aims are to test the significance of these pathways, define how input pathways engage the circuitry of V1 layers and compartments, and discern the strategies utilized by the output pathways to support V1 target areas. This proposal focuses on the K and the M input pathways and on output pathways to visual area 2 (V2), the dorsal medial visual area (DM), and the middle temporal visual area (MT). The specific aims are designed to test hypotheses generated by our working model. In Aim I, the PI will examine the K pathway and how this and other pathways are integrated within the CO-blobs of V1. In Aim II, she will determine the relationship of LGN K (or M) cell activity to eye movements or to behavioral relevance. In Aim III she will define the organization of V1 output pathways from CO-blob columns. The results of this proposed studies will contribute important new information to the fundamental understanding of how the brain processes visual information and of brain architecture in general.