VISUAL SYSTEM ORGANIZATION & DEVELOPMENT

研究的总体目标是了解功能 起源于视网膜的平行通路对 大脑皮层可视区域。这项提议代表着 网络环境下三个通道的并行处理研究 原猴灵长类的视觉系统，Galago。四个具体 此处概述的目标将调查转型的细节 外侧膝状体(LGN)的视觉信息和 纹状皮质。在目标一中，建议进行研究，以检验 W样细胞通路在LGN中的作用(这是好的 在加拉戈斯开发的)。将执行集群分析以 基于感受野确定LGN W样细胞亚型 属性。类W感受场属性的变化将是 丘脑激活或失活后的检查 以确定这一通路的作用。在AIM II中，我们 建议研究W-样细胞通路在纹状体中的作用 大脑皮层。细胞色素中细胞的感受野特性 将检查第三层中的氧化物球，以确定这些 细胞反映其LGN-W样细胞的生理特征 输入。大脑皮层“斑点”细胞属性的改变将 在LGN层失活后对ASO进行检查。在AIM III，纹状皮质IVα层和IVβ层中的细胞将 检查以确定生理特征是否可以 这反映了他们的微小细胞(X-Lik)和 巨细胞(Y-样)LGN输入。三叉神经的解剖联系 还将分析大脑皮层IVα层和IVβ层。最后， 在目标IV中，视网膜外和膝内调节 将通过分析LGN中的并行通道来研究 非视网膜输入的分布和来源以及细节 胆碱能传递。

The overall aim of the research is to understand the functional contribution of parallel pathways originating in the retina to cortical visual areas. The proposal represents a continuation of studies on parallel processing in three identified channels in the visual system of the prosimian primate, galago. The four specific aims outlined here will investigate details of the transformation of visual information in the lateral geniculate nucleus (LGN) and striate cortex. In Aim I, studies are proposed that will examine the role of the W-like cell pathway in the LGN (which is well developed in galagos). Cluster analyses will be performed to determine subtypes of LGN W-like cells based on receptive field properties. Changes in W-like receptive field properties will be examined following activation or inactivation of collicular neurons to determine the role of this pathway. In Aim II, we propose studies on the role of the W-like cell pathway in striate cortex. Receptive field properties of cells in the cytochrome oxidase "blobs" in layer III will be examined to determine if these cells reflect a physiological signature of their LGN W-like cell input. Changes in the properties of the cortical "blob" cells will aso be examined following inactivation of the LGN layers. In Aim III, cells in striate cortical layers IV alpha and IV beta will be examined to determine if a physiological signature can be established that reflects their parvocellular (X-lik) and magnocellular (Y-like) LGN inputs. Anatomical connections of cortical layers IV alpha and IV beta will also be analyzed. Finally, in Aim IV, the extraretinal and intrageniculate modulation of parallel channels in the LGN will be studed by analyzing the distribution and source of non-retinal inputs and details of cholinergic transmission.