CLINICAL ELECTROPHYSIOLOGY OF HUMAN CONE MECHANISMS

人体锥体机制的临床电生理学

• 批准号: 3258633
• 负责人: PETER GOURAS
• 金额: $ 9.77万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-04-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3258633
• 关键词: autosomal dominant trait; autosomal recessive trait; brightness discrimination; computer assisted diagnosis; cone cell; congenital vision disorder; diagnosis design /evaluation; diagnosis quality /standard; electrophysiology; electroretinography; evoked potentials; human subject; light adaptations; longitudinal human study; retinitis pigmentosa; rod cell; stimulus /response; visual stimulus

We shall use full field electro-retinography and visual evoked cortical response detection facilitated by electronic computer techniques to examine the pathophysiology of well defined forms of RP, autosomal dominant, autosomal recessive, and sex-linked forms of the disease, in cooperating and dedicated human subjects. The mechanism of adaptation of the cone electroretinogram (ERG) and visual evoked response (VER) will be studied during and after a full field adapting light of known brightness is on and then turned off the retina. The time course of recovery of the slope and amplitude of the a-wave, and the amplitude and implicit time of the b-wave of the cone ERG will be determined. The experiments will be done at several brightness levels and all will be compared with the cone ERG of normal subjects of comparable ages to the RP patients. In this way we hope to gain insight into the mechanism of cone (and possibly rod) adaptation in this disease. Additional support is requested to continue to follow on a monthly basis selected patients with RP in order to determine how reliable the cone ERG and VER are and can be made to be, the latter by following up clues to non-stationarity in the cone ERG we have discovered in our previous research.

我们将使用全田的电回归学和视觉唤起的皮质 电子计算机技术促进的响应检测以检查 RP，常染色体显性质量明确形式的病理生理学， 疾病的常染色体隐性和性别联系形式 和敬业的人类主题。 锥体试验图（ERG）和视觉的适应机制 诱发的响应（VER）将在整个场上和之后研究 适应已知亮度的光线已打开，然后关闭视网膜。 A波的坡度和振幅恢复的时间过程，以及 锥体ERG的B波的幅度和隐式时间将是 决定。 实验将在几个亮度水平上进行，并且 所有这些都将与可比的正常受试者的锥体进行比较 RP患者的年龄。 通过这种方式，我们希望深入了解 该疾病中锥体（以及可能的杆）适应机理。 要求额外的支持以每月继续遵循 精选的RP患者，以确定锥体ERG的可靠性 和Ver是并且可以成为，后者通过跟踪线索来 我们在以前发现的锥体中的非平稳性 研究。