PREDICTIVE AND DIAGNOSTIC SCREENING TEST FOR GLAUCOMA

青光眼的预测和诊断筛查测试

• 批准号: 3257990
• 负责人: ALFRED SOMMER
• 金额: $ 21.11万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-09-01 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3257990
• 关键词: disease /disorder proneness /risk; eye fundus photography; glaucoma test; histopathology; human subject; intraocular pressure; longitudinal human study; mass screening; prognosis; rod cell; visual fields

New techniques for photographing the nerve fiber layer and analyzing threshold perimetry have proved potentially sensitive and specific indices of early to mild glaucomatous optic nerve damage. During the second phase of this longitudinal prospective study over 1600 eyes with ocular hypertension, 250 with early glaucomatous field loss and an additional 200-400 normal controls will continue to undergo annual re-examination including masked, detailed manual kinetic and static perimetry, automated threshold perimetry, clinical assessment, color stereoscopic photography of the optic nerve head and red-free photography of the nerve fiber layer for an additional four years. Analysis will determine the sensitivity and specificity with which NFL assessment alone and, or in combination with other ocular, systemic and demographic factors, and with which threshold perimetry can identify individuals at risk of glaucomatous nerve damage (by manual perimetry or changes in cup-disc parameters, the existing "gold standards") at annual intervals before such loss occurs. In addition, the natural history of ocular hypertension and correlative changes in these eyes will be established. Findings may result in new operative definitions of glaucoma for diagnostic and screening purposes, permitting effective and efficient intervention earlier in the disease process.

神经纤维层摄影和分析的新技术 阈值视野检查已被证明是潜在的敏感和特异性指标 早期到轻度的昏迷性视神经损伤 在第二阶段期间 在这项纵向前瞻性研究中， 高血压，250例早期昏迷性视野丧失， 200-400名正常对照将继续进行年度复检 包括掩蔽的、详细的手动动态和静态视野检查，自动 阈值视野检查，临床评估，彩色立体摄影 视神经乳头和无红摄影的神经纤维层 再判四年 分析将确定NFL的敏感性和特异性， 单独评估和/或与其他眼部、全身和 人口统计学因素，以及阈值视野检查可以识别 有昏迷性神经损伤风险的个体（通过手动视野检查或 杯-盘参数的变化，现有的“黄金标准”） 在这种损失发生之前。 此外，自然历史 这些眼睛的高眼压和相关变化将是 确立了习 研究结果可能会导致新的青光眼诊断手术定义 和筛查目的，以便进行有效和高效的干预 在疾病的早期阶段。