RACIAL VARIATIONS IN CHRONIC OPEN ANGLE GLAUCOMA

在美国，青光眼是导致失明的主要原因之一。 在白人中，它排名第三，仅次于视网膜疾病和白内障 估计失明患病率为8.6/10万。在黑人中，它是 致盲率为72.0/10万，是导致失明的主要原因 比白人多七倍。这个项目的总体目标是 确定青光眼患病率大幅增加的原因 穿着黑色衣服眼花缭乱。这项研究将测量青光眼的患病率。 可比人群的视野丧失和高眼压 东巴尔的摩的白人和黑人，根据#年查明的案件 患病率调查，比较病例和患者的潜在危险因素 控制按种族分层。 东巴尔的摩家庭的两阶段概率样本将是 选定的及居住在该等住户中且年满40岁的所有人士 年龄或更大的人将接受视野丧失和抬高的筛查 邻里筛查中心的眼压。那些测试的人 视野丧失，眼压升高， 原因不明的视力下降，正常的样本将是 在威尔默眼科研究所进行评估，以进一步确定他们的诊断和 以确认筛查结果。这项研究的数据来源将 包括筛查和评估检查、人体测量、血液 压力，还有个人面谈。此外，样本的家庭 的病例和控制措施将在威尔默研究所进行审查 探讨家族性因素在慢性开角型青光眼中的作用。

Glaucoma is one of the leading causes of blindness in the United States. In whites it ranks third behind retinal diseases and cataract with an estimataed blindness prevalence of 8.6/100,000. In blacks, it is the leading cause of blindness with a blindness prevalence of 72.0/100,000, a seven-fold excess over whites. The general objective of this project is to determine the source of this greatly increased prevalence of glaucomatous blinding in blacks. This study will measure the prevalence of glaucomatous visual field loss and ocular hypertension in comparable populations of whites and blacks in East Baltimore and, based on the cases ascertained in the prevalence survey, compare the potential risk factors between cases and controls stratified by race. A two-stage probability sample of households in East Baltimore will be selected and all persons residing in those households who are 40 years of age or older will be screened for visual field loss and elevated intra-ocular pressure at neighborhood screening centers. Those who test positively for visual field loss, elevated intraocular pressure, unexplained reduction in visual acuity, and a sample of normal will be evaluated at the Wilmer Eye Institute to further define their diagnosis and to confirm the screening results. Sources of data for this study will include both screening and evaluation examinations, anthropometry, blood pressure, and a personal interview. In addition, the families of a sample of cases and controls will be examined at the Wilmer Institute to investigate the role of familial factors in chronic open angle glaucoma.