RACIAL VARIATIONS IN CHRONIC OPEN ANGLE GLAUCOMA

青光眼是美国的主要致盲原因之一。 在白人中，它排在视网膜疾病和白内障之后， 估计失明率为8.6/100，000。 在黑人中， 致盲率为72.0/100，000，a 超过白人的七倍 该项目的总体目标是 确定这一大大增加的流行性脑胶质瘤的来源， 在黑色中致盲。 这项研究将测量脑胶质瘤的患病率， 视野丧失和高眼压的可比人群中， 东巴尔的摩的白人和黑人，根据在 患病率调查，比较病例间潜在危险因素， 按人种分层的对照组。 东巴尔的摩的两阶段概率抽样家庭将是 被选中的人和所有居住在这些住户中的40岁以下的人 年龄或更大的将筛选视野丧失和升高 在附近的筛查中心进行眼内压检查。 那些测试 视野丧失眼内压升高 不明原因的视力下降，并将正常的样本 在威尔默眼科研究所进行评估，以进一步确定他们的诊断， 确认筛查结果 本研究的数据来源将 包括筛查和评估检查、人体测量、血液 压力和个人采访 此外，样本家庭 将在威尔默研究所对病例和对照进行检查， 探讨家族因素在慢性开角型青光眼中的作用。

Glaucoma is one of the leading causes of blindness in the United States. In whites it ranks third behind retinal diseases and cataract with an estimataed blindness prevalence of 8.6/100,000. In blacks, it is the leading cause of blindness with a blindness prevalence of 72.0/100,000, a seven-fold excess over whites. The general objective of this project is to determine the source of this greatly increased prevalence of glaucomatous blinding in blacks. This study will measure the prevalence of glaucomatous visual field loss and ocular hypertension in comparable populations of whites and blacks in East Baltimore and, based on the cases ascertained in the prevalence survey, compare the potential risk factors between cases and controls stratified by race. A two-stage probability sample of households in East Baltimore will be selected and all persons residing in those households who are 40 years of age or older will be screened for visual field loss and elevated intra-ocular pressure at neighborhood screening centers. Those who test positively for visual field loss, elevated intraocular pressure, unexplained reduction in visual acuity, and a sample of normal will be evaluated at the Wilmer Eye Institute to further define their diagnosis and to confirm the screening results. Sources of data for this study will include both screening and evaluation examinations, anthropometry, blood pressure, and a personal interview. In addition, the families of a sample of cases and controls will be examined at the Wilmer Institute to investigate the role of familial factors in chronic open angle glaucoma.