PREDICTIVE AND DIAGNOSTIC SCREENING TEST FOR GLAUCOMA

青光眼的预测和诊断筛查测试

• 批准号: 3257988
• 负责人: ALFRED SOMMER
• 金额: $ 23.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-09-01 至 1986-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3257988
• 关键词: disease /disorder proneness /risk; eye fundus photography; glaucoma test; histopathology; human subject; intraocular pressure; longitudinal human study; mass screening; prognosis; rod cell

The objectives of this study are to document and describe alterations in the appearance of the retinal nerve fiber layer that accompany glaucomatous visual field loss; and to determine the reliability and value of such changes, alone and in combination with the appearance of a variety of disc parameters, as a means of identifying individuals already having visual field loss, and predicting which ocular hypertensives will eventually develop field loss. Normal controls, ocular hypertensives, and patients with established glaucomatous field loss will be followed prospectively, repeatedly examined, and their disc and nerve fiber layer photographed. These photographs will be read in masked, randomized, controlled fashion and the sensitivity and specificity of the test, in temporal relationship to the eventual onset of glaucomatous field loss, determined.

本研究的目的是记录和描述 视网膜神经纤维层的出现伴随着青光眼 视野损失;并确定这种可靠性和价值 变化，单独和与各种光盘的外观组合 参数，作为识别已经具有视觉特征的个体的手段， 场损失，并预测哪些眼高血压患者最终将 出现磁场损耗。 正常对照、高眼压患者和患者 随着确定的昏迷性场损失将被前瞻性地跟踪， 反复检查，并拍摄其椎间盘和神经纤维层。 这些照片将以设盲、随机、对照的方式阅读 以及检测的灵敏度和特异性， 最终导致昏迷性磁场丧失